{[2-(4-amino-2-oxopyrimidin-1(2H)-yl)ethoxy]methyl}phosphonic acid

Base Information

• Chemical Name: {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)ethoxy]methyl}phosphonic acid
• CAS No.: 117087-39-5
• Molecular Formula: C₇H₁₂N₃O₅P
• Molecular Weight: 249.163
• Mol file: 117087-39-5.mol

Synonyms:Phosphonicacid, [[2-(4-amino-2-oxo-1(2H)-pyrimidinyl)ethoxy]methyl]- (9CI); 1-[2-(Phosphonomethoxy)ethyl]cytosine

Chemical Property of {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)ethoxy]methyl}phosphonic acid

Chemical Property:

• Vapor Pressure: 2.65E-12mmHg at 25°C
• Boiling Point: 522.2°Cat760mmHg
• Flash Point: 269.6°C
• Density: 1.71g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)ethoxy]methyl}phosphonic acid

There total 4 articles about {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)ethoxy]methyl}phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-<2-<(Diethylphosphonyl)methoxy>ethyl>cytosine (120362-31-4) → 1-[2-(Phosphonomethoxy)ethyl]cytosine (117087-39-5)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; for 14h; Ambient temperature;

DOI:10.1021/jm00127a010

Reference yield:

bis(2-propyl) 1-<2-(phosphonomethoxy)ethyl>cytosine (228874-11-1) → 1-[2-(Phosphonomethoxy)ethyl]cytosine (117087-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / Ambient temperature

2: aq. NH₃

With ammonium hydroxide; In acetonitrile;

DOI:10.1021/jm9811256

Reference yield:

C13H28N3O5PSi2 → 1-[2-(Phosphonomethoxy)ethyl]cytosine (117087-39-5)

Guidance literature:

With ammonium hydroxide; Yield given;

DOI:10.1021/jm9811256

upstream raw materials:

4-N-benzoylcytosine

toluene-4-sulfonic acid 2-(diethoxy-phosphorylmethoxy)-ethylester

1-<2-<(Diethylphosphonyl)methoxy>ethyl>cytosine

bis(2-propyl) 1-<2-(phosphonomethoxy)ethyl>cytosine