2,14-Dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one, 10-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-15-[(triphenyl methoxy)methyl]-, (1S,5S,6Z,9Z,13S,15S)-

Base Information

Chemical Name:2,14-Dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one, 10-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-15-[(triphenyl methoxy)methyl]-, (1S,5S,6Z,9Z,13S,15S)-
CAS No.:629614-55-7
Molecular Formula:C41H51ClO5Si
Molecular Weight:687.391
Hs Code.:

2,14-Dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one,
10-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-15-[(triphenyl
methoxy)methyl]-, (1S,5S,6Z,9Z,13S,15S)-

Synonyms:

Suppliers and Price of 2,14-Dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one, 10-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-15-[(triphenyl methoxy)methyl]-, (1S,5S,6Z,9Z,13S,15S)-

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Chemical Property of 2,14-Dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one, 10-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-15-[(triphenyl methoxy)methyl]-, (1S,5S,6Z,9Z,13S,15S)-

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Technology Process of 2,14-Dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one, 10-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-15-[(triphenyl methoxy)methyl]-, (1S,5S,6Z,9Z,13S,15S)-

There total 6 articles about 2,14-Dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one, 10-chloro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-15-[(triphenyl methoxy)methyl]-, (1S,5S,6Z,9Z,13S,15S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: C₄₈H₅₄Cl₄O₇Si

: 629614-55-7
(1S,5S,6Z,9Z,13S,15S)-5-(t-butyldimethylsilyloxy)-10-chloro-15-[(triphenylmethoxy)methyl]-6-methyl-2,14-dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one

Guidance literature:: With dmap; In tetrahydrofuran; toluene; at 20 ℃; for 17h;
DOI:10.1021/ol0356789

Reference yield:

: 76-83-5
trityl chloride

: 629614-55-7
(1S,5S,6Z,9Z,13S,15S)-5-(t-butyldimethylsilyloxy)-10-chloro-15-[(triphenylmethoxy)methyl]-6-methyl-2,14-dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / pyridine; DMAP / CH₂Cl₂ / 12 h / 20 °C

2: 93 percent / KOH; H₂O / 2-methyl-propan-2-ol / 6 h / 20 °C

3: Et₃N / tetrahydrofuran / 2 h / 20 °C

4: 65 percent / DMAP / toluene; tetrahydrofuran / 17 h / 20 °C

With pyridine; dmap; potassium hydroxide; water; triethylamine; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1021/ol0356789

Reference yield:

: (4Z,7Z)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-8-chloro-10-((4aS,6S,7aS)-2,2-dimethyl-tetrahydro-furo[3,2-d][1,3]dioxin-6-yl)-4-methyl-deca-4,7-dienoic acid phenyl ester

: 629614-55-7
(1S,5S,6Z,9Z,13S,15S)-5-(t-butyldimethylsilyloxy)-10-chloro-15-[(triphenylmethoxy)methyl]-6-methyl-2,14-dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / CSA; ethylene glycol / methanol / 2 h / 20 °C

2: 91 percent / pyridine; DMAP / CH₂Cl₂ / 12 h / 20 °C

3: 93 percent / KOH; H₂O / 2-methyl-propan-2-ol / 6 h / 20 °C

4: Et₃N / tetrahydrofuran / 2 h / 20 °C

5: 65 percent / DMAP / toluene; tetrahydrofuran / 17 h / 20 °C

With pyridine; dmap; potassium hydroxide; camphor-10-sulfonic acid; water; ethylene glycol; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1021/ol0356789