Chemical Property of CID 17751006
Chemical Property:
- Melting Point:224-225°C
- Boiling Point:565.2±50.0 °C(Predicted)
- PKA:4.65±0.10(Predicted)
- PSA：54.37000
- Density:1.07
- LogP:7.75200
- Storage Temp.:2-8°C
- XLogP3:7.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:5
- Exact Mass:454.34469533
- Heavy Atom Count:33
- Complexity:904
- Purity/Quality:
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99%, *data from raw suppliers
elemonic acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=CCCC(C1CCC2(C1(CCC3=C2CCC4C3(CCC(=O)C4(C)C)C)C)C)C(=O)O)C
- Isomeric SMILES:CC(=CCC[C@@H]([C@@H]1CC[C@]2(C1(CCC3=C2CCC4[C@@]3(CCC(=O)C4(C)C)C)C)C)C(=O)O)C
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Description
β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 μM) in vitro. β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 μM) in vitro.
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Uses
beta-Elemonic acid is found in herbs and spices. beta-Elemonic acid is a constituent of elemi resin. beta-Elemonic acid is a flavouring agent. β-Elemonic Acid inhibits cell proliferation of human lung adenocarcinoma A549 cells and role of MAPK, ROS activation and glutathione depletion. Elemonic acid is also a Pin1 inhibitors.
