1-(Triphenylmethyl)imidazole

Base Information

• Chemical Name: 1-(Triphenylmethyl)imidazole
• CAS No.: 15469-97-3
• Molecular Formula: C22H18N2
• Molecular Weight: 310.398
• Hs Code.: 2933290090
• Mol file: 15469-97-3.mol

Synonyms:Imidazole,1-trityl- (6CI,8CI);1-(Triphenylmethyl)imidazole;1-Tritylimidazole;CDD 3501;N-Tritylimidazole;

Chemical Property of 1-(Triphenylmethyl)imidazole

Chemical Property:

• Vapor Pressure: 6.57E-08mmHg at 25°C
• Melting Point: 220-224 °C
• Refractive Index: 1.606
• Boiling Point: 451.294 °C at 760 mmHg
• PKA: 6.34±0.30(Predicted)
• Flash Point: 226.734 °C
• PSA: 17.82000
• Density: 1.058 g/cm³
• LogP: 4.72330
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
• Water Solubility.: Insoluble in water.

Purity/Quality:

97% ^*data from raw suppliers

1-Tritylimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1-Tritylimidazole is a Clotrimazole (C587400) analog as antifungal agent. 1-(Triphenylmethyl)imidazole may be used in the synthesis of 1,2,5-trisubstituted imidazole derivatives.

Technology Process of 1-(Triphenylmethyl)imidazole

There total 14 articles about 1-(Triphenylmethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

1H-imidazole (288-32-4) + trityl chloride (76-83-5) → N-tritylimidazole (15469-97-3)

Guidance literature:

1H-imidazole; With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Large scale;

trityl chloride; In N,N-dimethyl-formamide; at 0 - 15 ℃; for 16h; Reagent/catalyst; Solvent; Large scale;

Reference yield: 82.7%

1H-imidazole (288-32-4) + triphenylmethyl alcohol (76-84-6) + diphenyl phosphite (102-10-3) → N-tritylimidazole (15469-97-3)

Guidance literature:

With pyridine; In acetonitrile;

Reference yield: 82.7%

→ N-tritylimidazole (15469-97-3)

Guidance literature:

upstream raw materials:

1H-imidazole

triphenylmethyl 4-cyanophenyl ether

trityl chloride

D-arabinopyranose

Downstream raw materials:

2-(phenylsulfanyl)-1-(triphenylmethyl)-1H-imidazole

2,5-dimethyl-1-(triphenylmethyl)imidazole

2-methyl-1-tritylimidazole

2-bromo-1H-imidazole