4-(2-CARBOXYETHYL)-3,5-DIMETHYLPYRROLE-2-CARBOXYLIC ACID, ETHYL ETHER

Base Information

• Chemical Name: 4-(2-CARBOXYETHYL)-3,5-DIMETHYLPYRROLE-2-CARBOXYLIC ACID, ETHYL ETHER
• CAS No.: 37789-64-3
• Molecular Formula: C12H17NO4
• Molecular Weight: 239.271
• Hs Code.: 2933990090
• Mol file: 37789-64-3.mol

Synonyms:2,4-Dimethyl-5-carboxy-1H-pyrrole-3-propanoic acid 5-ethyl ester;

Chemical Property of 4-(2-CARBOXYETHYL)-3,5-DIMETHYLPYRROLE-2-CARBOXYLIC ACID, ETHYL ETHER

Chemical Property:

• Vapor Pressure: 8.83E-08mmHg at 25°C
• Boiling Point: 419.3°C at 760 mmHg
• Flash Point: 207.4°C
• PSA: 79.39000
• Density: 1.204g/cm³
• LogP: 1.82540

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Carboxy-ethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-CARBOXYETHYL)-3,5-DIMETHYLPYRROLE-2-CARBOXYLIC ACID, ETHYL ETHER

There total 6 articles about 4-(2-CARBOXYETHYL)-3,5-DIMETHYLPYRROLE-2-CARBOXYLIC ACID, ETHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 5-(ethoxycarbonyl)-2,4-dimethyl-1H-pyrrole-3-propanoate (54278-10-3) → 4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (37789-64-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 20h; Ambient temperature;

DOI:10.1016/S0957-4166(97)00481-3

Reference yield: 90.0%

5-ethoxycarbonyl-2,4-dimethylpyrrole-3-acrylic acid (52649-02-2) → 4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (37789-64-3)

Guidance literature:

With hydrogen; nickel; In sodium hydroxide; for 12h; under 1551.4 Torr; Ambient temperature;

DOI:10.1016/0040-4020(90)80003-Z

Reference yield:

4-acetyl-5-oxohexanoic acid (54605-46-8) + diethyl oximinomalonate (6829-41-0) → 4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (37789-64-3)

Guidance literature:

With sodium acetate; acetic acid; zinc;

DOI:10.1021/ja01611a043

upstream raw materials:

4-acetyl-5-oxohexanoic acid

diethyl oximinomalonate

5-ethoxycarbonyl-2,4-dimethylpyrrole-3-acrylic acid

ethyl 5-(ethoxycarbonyl)-2,4-dimethyl-1H-pyrrole-3-propanoate

Downstream raw materials:

tert-butyl 3,5-dimethyl-4-(2-methoxycarbonylethyl)-1H-pyrrole-2-carboxylate

ethyl 3,5-dimethyl-4-(2-methoxycarbonyl-ethyl)pyrrole-2-carboxylate

coproporphyrin I

4-(2-benzyloxycarbonylethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester