Benzenepentanoic acid, 3,4-dichloro-5-methoxy-

Base Information

• Chemical Name: Benzenepentanoic acid, 3,4-dichloro-5-methoxy-
• CAS No.: 63001-45-6
• Molecular Formula: C12H14Cl2O3
• Molecular Weight: 277.147
• Mol file: 63001-45-6.mol

Synonyms:

Chemical Property of Benzenepentanoic acid, 3,4-dichloro-5-methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepentanoic acid, 3,4-dichloro-5-methoxy-

There total 7 articles about Benzenepentanoic acid, 3,4-dichloro-5-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3,4-dichloro-5-methoxyphenyl)penta-2,4-dienoic acid → 5-(3,4-dichloro-5-methoxyphenyl)valeric acid (63001-45-6)

Guidance literature:

With hydrogenchloride; sulfuric acid; rhodium; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol;

Reference yield:

3,4-Dichloro-5-hydroxybenzoic acid (63001-36-5) → 5-(3,4-dichloro-5-methoxyphenyl)valeric acid (63001-45-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide; potassium carbonate / N-methyl-acetamide; methanol; water

2: thionyl chloride; 5,5-dimethyl-1,3-cyclohexadiene; benzene

3: potassium hydroxide; potassium / methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; tert-butyl alcohol

4: hydrogenchloride; sulfuric acid / rhodium / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol

With hydrogenchloride; potassium hydroxide; sulfuric acid; potassium; potassium carbonate; rhodium; In N-methyl-acetamide; methanol; thionyl chloride; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; tert-butyl alcohol; benzene;

Reference yield:

3,4-dichloro-5-methoxybenzoic acid (63001-37-6) → 5-(3,4-dichloro-5-methoxyphenyl)valeric acid (63001-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride; 5,5-dimethyl-1,3-cyclohexadiene; benzene

2: potassium hydroxide; potassium / methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; tert-butyl alcohol

3: hydrogenchloride; sulfuric acid / rhodium / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol

With hydrogenchloride; potassium hydroxide; sulfuric acid; potassium; rhodium; In methanol; thionyl chloride; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; tert-butyl alcohol; benzene;

upstream raw materials:

2-ethyl-5-hydroxy-6,7-dichloro-1-indanone

6,7-dichloro-2-ethyl-5-methoxy-2,3-dihydro-1H-inden-1-one

3,4-dichloro-5-methoxybenzaldehyde

3,4-Dichloro-5-hydroxybenzoic acid