2,6-Difluoropyrazine

Base Information

• Chemical Name: 2,6-Difluoropyrazine
• CAS No.: 33873-09-5
• Molecular Formula: C4H2F2N2
• Molecular Weight: 116.07
• Hs Code.: 2933990090
• Mol file: 33873-09-5.mol

Synonyms:Pyrazine,2,6-difluoro;2,6-Difluorpyrazin;2,6-difluoro-pyrazine;

Chemical Property of 2,6-Difluoropyrazine

Chemical Property:

• Vapor Pressure: 30.2mmHg at 25°C
• Refractive Index: 1.444
• Boiling Point: 108.6°Cat760mmHg
• PKA: -3.45±0.10(Predicted)
• Flash Point: 19.5°C
• PSA: 25.78000
• Density: 1.376g/cm³
• LogP: 0.75480

Purity/Quality:

97% ^*data from raw suppliers

2,6-Difluoropyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Difluoropyrazine is used in the preparation of pyrazolopyrimidines which may be used against respiratory syncytial virus. Also used in the preparation of 2,6-diphenoxypyridine factor Xa inhibitors.

Technology Process of 2,6-Difluoropyrazine

There total 2 articles about 2,6-Difluoropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloropyrazine (4774-14-5) → 2,6-difluoropyrazine (33873-09-5)

Guidance literature:

With tetrabutyl phosphonium hydrogen difluoride; at 80 ℃; for 1h;

Reference yield:

→ 2,6-difluoropyrazine (33873-09-5)

Guidance literature:

2,6 Cl2-pyrazin, KF;

DOI:10.1039/j39710002977

Reference yield: 65.0%

2-bromo-4-chlorophenol (695-96-5) + 2,6-difluoropyrazine (33873-09-5) → C10H5BrClFN2O

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 145 ℃; Inert atmosphere;

upstream raw materials:

2,6-dichloropyrazine

Downstream raw materials:

3,3'-<2,6-pyrazinediylbis(oxy)>bis(benzonitrile)

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