Benzyl 6-hydroxy-2,3-dimethoxybenzoate

Base Information

Chemical Name:Benzyl 6-hydroxy-2,3-dimethoxybenzoate
CAS No.:63147-21-7
Molecular Formula:C16H16O5
Molecular Weight:288.3
Hs Code.:
DSSTox Substance ID:DTXSID10565271
Wikidata:Q82450278

Synonyms:Benzyl 6-hydroxy-2,3-dimethoxybenzoate;63147-21-7;DTXSID10565271

Suppliers and Price of Benzyl 6-hydroxy-2,3-dimethoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzyl 6-hydroxy-2,3-dimethoxybenzoate

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:288.09977361
Heavy Atom Count:21
Complexity:327

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=C(C=C1)O)C(=O)OCC2=CC=CC=C2)OC

Technology Process of Benzyl 6-hydroxy-2,3-dimethoxybenzoate

There total 3 articles about Benzyl 6-hydroxy-2,3-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2033-89-8
3,4-dimethoxyphenol

: 63147-21-7
2,3-dimethoxy-6-hydroxybenzoic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 2.5 h, 2.) a) 0 deg C, 0.5 h, b) RT, 2.5 h

2: 1.) n-BuLi / 1.) Et₂O, TMEDA, hexane, 0 deg C, 1 h, 2.) from 0 deg C to RT

3: (COCl)2, DMF / CH₂Cl₂ / 1 h / 0 °C

4: CH₂Cl₂ / 1.5 h / 0 °C

With n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00109a013

Reference yield:

: 133129-57-4
2,3-dimethoxy-6-(methoxymethyl)benzoic acid

: 63147-21-7
2,3-dimethoxy-6-hydroxybenzoic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2, DMF / CH₂Cl₂ / 1 h / 0 °C

2: CH₂Cl₂ / 1.5 h / 0 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00109a013