Imidazo(1,2-a)pyridine-3-acetic acid, 2-methyl-

Base Information

• Chemical Name: Imidazo(1,2-a)pyridine-3-acetic acid, 2-methyl-
• CAS No.: 17745-07-2
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.202
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00170313
• Nikkaji Number: J40.940E
• Wikidata: Q83040225
• Mol file: 17745-07-2.mol

Synonyms:17745-07-2;2-(2-methylimidazo[1,2-a]pyridin-3-yl)acetic acid;Imidazo(1,2-a)pyridine-3-acetic acid, 2-methyl-;(2-methylimidazo[1,2-a]pyridin-3-yl)acetic acid;(2-Methyl-imidazo[1,2-a]pyridin-3-yl)-acetic acid;BRN 0786675;2-Methylimidazo(1,2-a)pyridine-3-acetic acid;(2-Methyl-3-imidazo(1,2-a)pyridine)acetic acid;2-{2-methylimidazo[1,2-a]pyridin-3-yl}acetic acid;MFCD01720480;Imidazo[1,2-a]pyridine-3-acetic acid, 2-methyl-;2-(2-Methylimidazo[1,2-a]pyridin-3-yl)aceticacid;2-Methylimidazo[1,2-a]pyridine-3-acetic acid;(2-Methyl-imidazo[1,2-a]pyridin-3-yl)acetic acid;SCHEMBL16156201;DTXSID00170313;BBL011209;STK934284;AKOS000271906;FS-5916;LS-80218;CS-0243795;EN300-2685101

Chemical Property of Imidazo(1,2-a)pyridine-3-acetic acid, 2-methyl-

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 54.60000
• Density: 1.3g/cm³
• LogP: 1.26980
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 190.074227566
• Heavy Atom Count: 14
• Complexity: 232

Purity/Quality:

98%min ^*data from raw suppliers

(2-methylimidazo[1,2-a]pyridin-3-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N2C=CC=CC2=N1)CC(=O)O

Technology Process of Imidazo(1,2-a)pyridine-3-acetic acid, 2-methyl-

There total 4 articles about Imidazo(1,2-a)pyridine-3-acetic acid, 2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

ethyl 2-methylimidazo<1,2-a>pyridine-3-acetate → 2-Methyl-3-carboxymethyl-imidazo<1.2-a>pyridin (17745-07-2)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 0.5h; Ambient temperature;

Reference yield:

2-aminopyridine (504-29-0) → 2-Methyl-3-carboxymethyl-imidazo<1.2-a>pyridin (17745-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 23 percent / ethanol / 6 h / Heating

2: 56 percent / 1 N NaOH / ethanol; H₂O / 0.5 h / Ambient temperature

With sodium hydroxide; In ethanol; water;

Reference yield:

ethyl 3-bromo-4-oxopentanoate (54260-84-3) → 2-Methyl-3-carboxymethyl-imidazo<1.2-a>pyridin (17745-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 23 percent / ethanol / 6 h / Heating

2: 56 percent / 1 N NaOH / ethanol; H₂O / 0.5 h / Ambient temperature

With sodium hydroxide; In ethanol; water;

upstream raw materials:

2-aminopyridine

ethyl 3-bromo-4-oxopentanoate

Refernces

• 1、 Abignente,Arena,Luraschi,Saturnino,Marmo,Russo,Magliulo. "Research on heterocyclic compounds. XIX. 2-Methylimidazo[1,2-a ]pyridine-3-acetic acids". . p. 119 - 130. Retrieved 2007/10/02.