[4,5-Dimethoxy-2-(morpholine-4-sulfonyl)phenyl]acetic acid

Base Information

• Chemical Name: [4,5-Dimethoxy-2-(morpholine-4-sulfonyl)phenyl]acetic acid
• CAS No.: 63212-44-2
• Molecular Formula: C₁₄H₁₉NO₇S
• Molecular Weight: 345.373
• DSSTox Substance ID: DTXSID90377834
• Wikidata: Q82167191
• Mol file: 63212-44-2.mol

Synonyms:63212-44-2;[4,5-dimethoxy-2-(morpholine-4-sulfonyl)phenyl]acetic acid;2-(4,5-dimethoxy-2-morpholin-4-ylsulfonylphenyl)acetic acid;2-(4,5-Dimethoxy-2-(morpholinosulfonyl)phenyl)acetic acid;Benzeneacetic acid, 4,5-dimethoxy-2-(4-morpholinylsulfonyl)-;DTXSID90377834;[4,5-Dimethoxy-2-(morpholine-4-sulfonyl)-phenyl]-acetic acid;AKOS022169244;MS-11457;[4,5-Dimethoxy-2-(morpholine-4-sulfonyl)phenyl]aceticacid;2-(4,5-Dimethoxy-2-(morpholinosulfonyl)phenyl)aceticacid;2-[4,5-dimethoxy-2-(morpholine-4-sulfonyl)phenyl]acetic acid

Chemical Property of [4,5-Dimethoxy-2-(morpholine-4-sulfonyl)phenyl]acetic acid

Chemical Property:

• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 345.08822312
• Heavy Atom Count: 23
• Complexity: 498

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C(=C1)CC(=O)O)S(=O)(=O)N2CCOCC2)OC

Technology Process of [4,5-Dimethoxy-2-(morpholine-4-sulfonyl)phenyl]acetic acid

There total 2 articles about [4,5-Dimethoxy-2-(morpholine-4-sulfonyl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H21NO7S (343832-73-5) → [4,5-dimethoxy-2-(morpholine-4-sulfonyl)-phenyl]-acetic acid (63212-44-2)

Guidance literature:

C₁₅H₂₁NO₇S; With lithium hydroxide; In tetrahydrofuran; methanol;

Acidic aq. solution;

DOI:10.1016/j.bmcl.2007.11.116

Reference yield:

ethyl [2-(morpholine-4-sulfonyl)-4,5-dimethoxy-phenyl]acetate (35189-66-3) → [4,5-dimethoxy-2-(morpholine-4-sulfonyl)-phenyl]-acetic acid (63212-44-2)

Guidance literature:

With methanol; potassium hydroxide;

Reference yield:

[4,5-dimethoxy-2-(morpholine-4-sulfonyl)-phenyl]-acetic acid (63212-44-2) → [4,5-dimethoxy-2-(morpholine-4-sulfonyl)-phenyl]-acetyl chloride (66079-59-2)

Guidance literature:

With thionyl chloride;

upstream raw materials:

ethyl [2-(morpholine-4-sulfonyl)-4,5-dimethoxy-phenyl]acetate

C₁₅H₂₁NO₇S

Downstream raw materials:

[4,5-dimethoxy-2-(morpholine-4-sulfonyl)-phenyl]-acetyl chloride

4-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-ylmethyl)-4,5-dimethoxy-benzenesulfonyl]-morpholine

[4,5-dimethoxy-2-(morpholine-4-sulfonyl)-phenyl]-acetic acid 2-morpholin-4-yl-ethyl ester

[4,5-dimethoxy-2-(morpholine-4-sulfonyl)-phenyl]-acetic acid 2-piperidin-1-yl-ethyl ester