3-Phenyl-2-(quinoline-2-carbonylamino)propanoic acid

Base Information

Chemical Name:3-Phenyl-2-(quinoline-2-carbonylamino)propanoic acid
CAS No.:6308-53-8
Molecular Formula:C19H16N2O3
Molecular Weight:320.34
Hs Code.:
NSC Number:42084
DSSTox Substance ID:DTXSID30285505
Nikkaji Number:J899.039E
Mol file:6308-53-8.mol

Synonyms:6308-53-8;3-Phenyl-2-(quinoline-2-carboxamido)propanoic acid;3-phenyl-2-(quinoline-2-carbonylamino)propanoic acid;NSC42084;DTXSID30285505;NSC-42084;3-phenyl-2-[(quinolin-2-yl)formamido]propanoic acid

Suppliers and Price of 3-Phenyl-2-(quinoline-2-carbonylamino)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 3-Phenyl-2-(quinoline-2-carbonylamino)propanoic acid

Chemical Property:

Vapor Pressure:1.56E-16mmHg at 25°C
Boiling Point:626°C at 760 mmHg
Flash Point:332.4°C
PSA：79.29000
Density:1.303g/cm³
LogP:3.05140
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:320.11609238
Heavy Atom Count:24
Complexity:448

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(C(=O)O)NC(=O)C2=NC3=CC=CC=C3C=C2

Technology Process of 3-Phenyl-2-(quinoline-2-carbonylamino)propanoic acid

There total 11 articles about 3-Phenyl-2-(quinoline-2-carbonylamino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₈N₂O₃

: 6308-53-8
(S)-3-phenyl-2-(quinoline-2-carboxamido)propanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1055/s-0033-1339550

Reference yield:

: (R)-3-Phenyl-2-[(quinoline-2-carbonyl)-amino]-propionic acid methyl ester

: 115732-19-9,6308-53-8
(R)-3-Phenyl-2-[(quinoline-2-carbonyl)-amino]-propionic acid

Guidance literature:: With sodium hydroxide; In methanol; for 0.166667h; Yield given;
DOI:10.1021/jm00119a007

Reference yield:

: 93-10-7,1199266-78-8
quinoline-2-carboxylic acid

: 115732-19-9,6308-53-8
(R)-3-Phenyl-2-[(quinoline-2-carbonyl)-amino]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: DCC / CHCl₃ / 3 h

2: 24 h / 25 °C

3: aq. NaOH / methanol / 0.17 h

With sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; chloroform;
DOI:10.1021/jm00119a007