methyl N-[(benzyloxy)carbonyl]glycylglycylleucinate

Base Information

• Chemical Name: methyl N-[(benzyloxy)carbonyl]glycylglycylleucinate
• CAS No.: 55260-11-2
• Molecular Formula: C19H27N3O6
• Molecular Weight: 393.4342
• NSC Number: 169115
• DSSTox Substance ID: DTXSID70305094
• Mol file: 55260-11-2.mol

Synonyms:55260-11-2;NSC169115;DTXSID70305094;AKOS024432447;NSC-169115;methyl N-[(benzyloxy)carbonyl]glycylglycylleucinate;CARBOBENZYLOXYGLYCYLGLYCYL-L-LEUCINE METHYL ESTER

Chemical Property of methyl N-[(benzyloxy)carbonyl]glycylglycylleucinate

Chemical Property:

• Vapor Pressure: 2.58E-16mmHg at 25°C
• Boiling Point: 640.8°Cat760mmHg
• Flash Point: 341.3°C
• Density: 1.184g/cm³
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 12
• Exact Mass: 393.18998559
• Heavy Atom Count: 28
• Complexity: 532

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)OC)NC(=O)CNC(=O)CNC(=O)OCC1=CC=CC=C1

Technology Process of methyl N-[(benzyloxy)carbonyl]glycylglycylleucinate

There total 2 articles about methyl N-[(benzyloxy)carbonyl]glycylglycylleucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Leu-OMe (2666-93-5) + Z-Gly-Gly-N3 (41445-96-9) → N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-L-leucine methyl ester (55260-11-2)

Guidance literature:

With ethyl acetate;

Reference yield:

→ N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-D-leucine methyl ester (55260-11-2)

Guidance literature:

/0605413451003/;

Reference yield:

N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-L-leucine methyl ester (55260-11-2) → glycylglycyl-(L)-leucine (14857-82-0,855529-10-1)

Guidance literature:

With sodium hydroxide; durch Verseifung und Hydrogenolyse des Reaktionsprodukts an Palladium in Methanol;

upstream raw materials:

(S)-Leu-OMe

Z-Gly-Gly-N₃

Downstream raw materials:

glycylglycyl-(L)-leucine

Cbz-Gly-Gly-L-Leu-OH

Z-Gly-Gly-Leu-NH₂

Gly-Gly-d-Leu