2-Pyridinecarboxylic acid, 6-[2-[2-[(2,3-difluorophenyl)methoxy]-5-(trifluoromethyl)phenyl]-5-methyl- 1H-pyrrol-1-yl]-

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid, 6-[2-[2-[(2,3-difluorophenyl)methoxy]-5-(trifluoromethyl)phenyl]-5-methyl- 1H-pyrrol-1-yl]-
• CAS No.: 632623-87-1
• Molecular Formula: C25H17F5N2O3
• Molecular Weight: 488.414
• Mol file: 632623-87-1.mol

Synonyms:

Chemical Property of 2-Pyridinecarboxylic acid, 6-[2-[2-[(2,3-difluorophenyl)methoxy]-5-(trifluoromethyl)phenyl]-5-methyl- 1H-pyrrol-1-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinecarboxylic acid, 6-[2-[2-[(2,3-difluorophenyl)methoxy]-5-(trifluoromethyl)phenyl]-5-methyl- 1H-pyrrol-1-yl]-

There total 7 articles about 2-Pyridinecarboxylic acid, 6-[2-[2-[(2,3-difluorophenyl)methoxy]-5-(trifluoromethyl)phenyl]-5-methyl- 1H-pyrrol-1-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-{2-[5-trifluoromethyl-2-(2,3-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-picolinic acid-(2,3-difluorobenzyl)ester → 6-{2-[5-trifluoromethyl-2-(2,3-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-picolinic acid (632623-87-1)

Guidance literature:

With sodium hydroxide; water; In ethanol; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

2-benzyloxy-5-trifluoromethylbenzaldehyde (632626-08-5) → 6-{2-[5-trifluoromethyl-2-(2,3-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-picolinic acid (632623-87-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 22 h / Heating / reflux

2.1: toluene-4-sulfonic acid / acetonitrile / 1.5 h / 200 °C / Microwave irradiation

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C

3.2: -78 - 20 °C

4.1: ammonium formate / palladium 10% on activated carbon / ethanol / 1 h / 60 °C

5.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 40 h / 60 °C

6.1: sodium hydroxide; water / ethanol / 0.25 h / 120 °C / Microwave irradiation

With sodium hydroxide; n-butyllithium; water; ammonium formate; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; palladium 10% on activated carbon; toluene-4-sulfonic acid; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; hexane; acetonitrile;

Reference yield:

1-[5-trifluoromethyl-2-(benzyloxy)-phenyl]-pentane-1,4-dione (632626-09-6) → 6-{2-[5-trifluoromethyl-2-(2,3-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-picolinic acid (632623-87-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / acetonitrile / 1.5 h / 200 °C / Microwave irradiation

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C

2.2: -78 - 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 1 h / 60 °C

4.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 40 h / 60 °C

5.1: sodium hydroxide; water / ethanol / 0.25 h / 120 °C / Microwave irradiation

With sodium hydroxide; n-butyllithium; water; ammonium formate; potassium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; hexane; acetonitrile;

upstream raw materials:

2-benzyloxy-5-trifluoromethylbenzaldehyde

1-[5-trifluoromethyl-2-(benzyloxy)-phenyl]-pentane-1,4-dione

6-{2-[5-trifluoromethyl-2-(hydroxy)phenyl]-5-methyl-pyrrol-1-yl}-picolinic acid

6-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-2-bromopyridine