Quinoline, 1-(bromoacetyl)-1,2,3,4-tetrahydro-

Base Information

• Chemical Name: Quinoline, 1-(bromoacetyl)-1,2,3,4-tetrahydro-
• CAS No.: 63286-44-2
• Molecular Formula: C11H12BrNO
• Molecular Weight: 254.126

Synonyms:2-bromo-1-(3,4-dihydro-2H-quinolin-1-yl)-ethanone;N-(2-bromoacetyl)-1,2,3,4-tetrahydroquinoline;1-(Bromoacetyl)-1,2,3,4-tetrahydroquinoline;1-(2-bromoacetyl)-1,2,3,4-tetrahydroquinoline;

Chemical Property of Quinoline, 1-(bromoacetyl)-1,2,3,4-tetrahydro-

Chemical Property:

• Vapor Pressure: 4.25E-07mmHg at 25°C
• Boiling Point: 415oC at 760 mmHg
• Flash Point: 204.8oC
• PSA: 20.31000
• Density: 1.479g/cm3
• LogP: 2.42570

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinoline, 1-(bromoacetyl)-1,2,3,4-tetrahydro-

There total 2 articles about Quinoline, 1-(bromoacetyl)-1,2,3,4-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + 2-Bromoacetyl bromide (598-21-0) → 1-(2-bromoacetyl)-1,2,3,4-tetrahydroquinoline (63286-44-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h;

DOI:10.1016/j.tet.2019.130711

Reference yield:

→ 1-(2-bromoacetyl)-1,2,3,4-tetrahydroquinoline (63286-44-2)

Guidance literature:

Reference yield: 84.0%

1-(2-bromoacetyl)-1,2,3,4-tetrahydroquinoline (63286-44-2) + 1-phenyl-4-(piperazin-1-yl)quinolin-2(1H)-one → 4-(4-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl)piperazin-1-yl)-1-phenylquinolin-2(1H)-one

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bioorg.2022.105631

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

2-Bromoacetyl bromide

Downstream raw materials:

rac-1-(3,4-dihydro-2H-quinolin-1-yl)-2-(1-phenyl-ethylamino)-ethanone trifluoroacetate

(R)-2-(1-methylbenzylamino)-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

(RS)-2-(1-methylbenzylamino)-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

2-(diphenylmethylamino)-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

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