Cyclohexanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-1-(2-propenyl)-6-[(trimethylsilyl)oxy]-, (1S,2R,4R,6S)-

Base Information

Chemical Name:Cyclohexanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-1-(2-propenyl)-6-[(trimethylsilyl)oxy]-, (1S,2R,4R,6S)-
CAS No.:633294-41-4
Molecular Formula:C34H56O4Si3
Molecular Weight:613.073
Hs Code.:

Cyclohexanol,
2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[(1,1-dimethylethyl)diphenylsil
yl]oxy]-1-(2-propenyl)-6-[(trimethylsilyl)oxy]-, (1S,2R,4R,6S)-

Synonyms:

Suppliers and Price of Cyclohexanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-1-(2-propenyl)-6-[(trimethylsilyl)oxy]-, (1S,2R,4R,6S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-1-(2-propenyl)-6-[(trimethylsilyl)oxy]-, (1S,2R,4R,6S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of Cyclohexanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-1-(2-propenyl)-6-[(trimethylsilyl)oxy]-, (1S,2R,4R,6S)-

There total 4 articles about Cyclohexanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[(1,1-dimethylethyl)diphenylsil yl]oxy]-1-(2-propenyl)-6-[(trimethylsilyl)oxy]-, (1S,2R,4R,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 2622-05-1
allylmagnesium bromide

: 633294-34-5
(2R,4R,6S)-2-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)-6-trimethylsilyloxy-cyclohexanone

: 633294-41-4
(1S,2R,4R,6S)-1-allyl-2-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)-6-trimethylsilyloxy-cyclohexanol

: (1R,2R,4R,6S)-1-allyl-2-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)-6-trimethylsilyloxy-cyclohexanol

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;
DOI:10.1055/s-2003-41025

Reference yield:

: 633294-17-4
(1S,3R,5R,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-7-oxabicyclo[4.1.0]heptan-3-ol

: 633294-41-4
(1S,2R,4R,6S)-1-allyl-2-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)-6-trimethylsilyloxy-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / imidazole / dimethylformamide / 3 h / 20 °C

2.1: 89 percent / diethylaluminium N-cyclohexyl-N-iso-propylamide / benzene / 3 h / 20 °C

3.1: 100 percent / imidazole / dimethylformamide / 4 h / 20 °C

4.1: O₃; Et₃N / methanol; CH₂Cl₂ / -78 °C

4.2: 85 percent / Me₂S / methanol; CH₂Cl₂ / 2.5 h / -78 - 20 °C

5.1: 56 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C

With 1H-imidazole; diethylaluminium N-cyclohexyl-N-iso-propylamide; ozone; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-2003-41025

Reference yield:

: 633294-15-2
tert-butyl-[(1R,2R,4R,6S)-4-iso-propenyl-1-methyl-7-oxabicyclo[4.1.0]hept-2-yloxy]dimethylsilane

: 633294-41-4
(1S,2R,4R,6S)-1-allyl-2-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)-6-trimethylsilyloxy-cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: O₃ / methanol; CH₂Cl₂ / -78 °C

1.2: Ac₂O; Et₃N; DMAP / methanol; CH₂Cl₂ / 12 h / Heating

1.3: 68 percent / K₂CO₃ / methanol / 3 h / 20 °C

2.1: 88 percent / imidazole / dimethylformamide / 3 h / 20 °C

3.1: 89 percent / diethylaluminium N-cyclohexyl-N-iso-propylamide / benzene / 3 h / 20 °C

4.1: 100 percent / imidazole / dimethylformamide / 4 h / 20 °C

5.1: O₃; Et₃N / methanol; CH₂Cl₂ / -78 °C

5.2: 85 percent / Me₂S / methanol; CH₂Cl₂ / 2.5 h / -78 - 20 °C

6.1: 56 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C

With 1H-imidazole; diethylaluminium N-cyclohexyl-N-iso-propylamide; ozone; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-2003-41025