2,6-Octanediol,1-[(2S,4S,6R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-2H-pyran-2-yl]-8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-methylene-, 2-methanesulfonate,(2S,6R)-

Base Information

Chemical Name:2,6-Octanediol,1-[(2S,4S,6R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-2H-pyran-2-yl]-8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-methylene-, 2-methanesulfonate,(2S,6R)-
CAS No.:633305-60-9
Molecular Formula:C47H77NO9SSi3
Molecular Weight:916.452
Hs Code.:

2,6-Octanediol,1-[(2S,4S,6R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-2H-pyran-2-yl]-8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-methylene-, 2-methanesulfonate,(2S,6R)-

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Chemical Property of 2,6-Octanediol,1-[(2S,4S,6R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-2H-pyran-2-yl]-8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-methylene-, 2-methanesulfonate,(2S,6R)-

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Technology Process of 2,6-Octanediol,1-[(2S,4S,6R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-2H-pyran-2-yl]-8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-methylene-, 2-methanesulfonate,(2S,6R)-

There total 8 articles about 2,6-Octanediol,1-[(2S,4S,6R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-oxazolyl]tetrahydro-2H-pyran-2-yl]-8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-methylene-, 2-methanesulfonate,(2S,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 633305-66-5
(R)-tert-butyl-(3-(4-methoxybenzyloxy)hex-5-enyloxy)-diphenylsilane

: 633305-60-9
methanesulfonic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 86 percent / aq. CuCl; oxygen / PdCl₂ / dimethylformamide / 12 h / 20 °C

2.1: LiHMDS / tetrahydrofuran / -78 °C

3.1: TiCl₄ / tetrahydrofuran / 0.5 h / -78 °C

3.2: 334 mg / tetrahydrofuran / 2 h / -78 °C

4.1: DMAP; pyridine / 3 h / 20 °C

5.1: 411 mg / 4 Angstroem molecular sieves; TiCl₄ / tetrahydrofuran / 3.25 h / 0 - 20 °C

6.1: DIBAL / CH₂Cl₂; toluene / 1 h / -78 °C

7.1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

8.1: 32 mg / DDQ / CH₂Cl₂ / 2 h / 20 °C / pH 7

With pyridine; dmap; 4 A molecular sieve; oxygen; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(l) chloride; lithium hexamethyldisilazane; palladium dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Wacker oxidation;
DOI:10.1002/chem.200500892

Reference yield:

: methanesulfonic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyl ester

: 633305-60-9
methanesulfonic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl]-but-3-enyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water;
DOI:10.1055/s-2003-41462

Reference yield:

: 633305-55-2
6-(tert-butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-hexan-2-one

: 633305-60-9
methanesulfonic acid 1-{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-3-[4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: LiHMDS / tetrahydrofuran / -78 °C

2.1: TiCl₄ / tetrahydrofuran / 0.5 h / -78 °C

2.2: 334 mg / tetrahydrofuran / 2 h / -78 °C

3.1: DMAP; pyridine / 3 h / 20 °C

4.1: 411 mg / 4 Angstroem molecular sieves; TiCl₄ / tetrahydrofuran / 3.25 h / 0 - 20 °C

5.1: DIBAL / CH₂Cl₂; toluene / 1 h / -78 °C

6.1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

7.1: 32 mg / DDQ / CH₂Cl₂ / 2 h / 20 °C / pH 7

With pyridine; dmap; 4 A molecular sieve; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.200500892