trans-2-(N-(2-Hydroxyindane-1-yl)imino)-3-acetylthiazolidine

Base Information

• Chemical Name: trans-2-(N-(2-Hydroxyindane-1-yl)imino)-3-acetylthiazolidine
• CAS No.: 141034-18-6
• Molecular Formula: C₁₄H₁₆N₂O₂S
• Molecular Weight: 276.359
• DSSTox Substance ID: DTXSID20930976
• Mol file: 141034-18-6.mol

Synonyms:BRN 5350324;trans-2-(N-(2-Hydroxyindane-1-yl)imino)-3-acetylthiazolidine;2-Thiazolidinimine, 3-acetyl-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-, trans-;trans-3-Acetyl-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-2-thiazolidinimine;Ethanone, 1-(2-((2-hydroxy-2,3-dihydro-1H-inden-1-yl)imino)-3-thiazolidinyl)-, (E)-;141034-18-6;DTXSID20930976;LS-151584;1-[3-(2-Hydroxy-2,3-dihydro-1H-inden-1-yl)-2-imino-1,3-thiazolidin-5-yl]ethan-1-one

Chemical Property of trans-2-(N-(2-Hydroxyindane-1-yl)imino)-3-acetylthiazolidine

Chemical Property:

• Vapor Pressure: 6.37E-09mmHg at 25°C
• Boiling Point: 451°Cat760mmHg
• Flash Point: 226.6°C
• Density: 1.46g/cm³
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 276.09324893
• Heavy Atom Count: 19
• Complexity: 401

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1CN(C(=N)S1)C2C(CC3=CC=CC=C23)O
• Isomeric SMILES: CC(=O)C1CN(C(=N)S1)[C@H]2[C@@H](CC3=CC=CC=C23)O

Technology Process of trans-2-(N-(2-Hydroxyindane-1-yl)imino)-3-acetylthiazolidine

There total 4 articles about trans-2-(N-(2-Hydroxyindane-1-yl)imino)-3-acetylthiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + trans-2-iminothiazolidine (141034-16-4) → trans-2-imino-3-acetyl thiazolidine (141034-18-6)

Guidance literature:

In methanol; for 7h; Heating;

DOI:10.1135/cccc19920415

Reference yield:

trans-1-aminoindan-2-ol (7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8) → trans-2-imino-3-acetyl thiazolidine (141034-18-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / acetone / 1 h / Heating

2: 76 percent / aq. NaOH / 1 h / Heating

3: 56 percent / ethanol / 36 h / Heating

4: 98 percent / methanol / 7 h / Heating

With sodium hydroxide; In methanol; ethanol; acetone;

DOI:10.1135/cccc19920415

Reference yield:

trans-N-(2-hydroxyindane-1-yl)-N'-benzoyl thiourea (141034-12-0) → trans-2-imino-3-acetyl thiazolidine (141034-18-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / aq. NaOH / 1 h / Heating

2: 56 percent / ethanol / 36 h / Heating

3: 98 percent / methanol / 7 h / Heating

With sodium hydroxide; In methanol; ethanol;

DOI:10.1135/cccc19920415

upstream raw materials:

acetic anhydride

trans-2-iminothiazolidine

trans-1-aminoindan-2-ol

trans-N-(2-hydroxyindane-1-yl) thiourea