1,3,4-Oxadiazole, 2-(4-ethynylphenyl)-5-[3,4,5-tris(dodecyloxy)phenyl]-

Base Information

• Chemical Name: 1,3,4-Oxadiazole, 2-(4-ethynylphenyl)-5-[3,4,5-tris(dodecyloxy)phenyl]-
• CAS No.: 633315-54-5
• Molecular Formula: C52H82N2O4
• Molecular Weight: 799.234
• Mol file: 633315-54-5.mol

Synonyms:

Chemical Property of 1,3,4-Oxadiazole, 2-(4-ethynylphenyl)-5-[3,4,5-tris(dodecyloxy)phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,4-Oxadiazole, 2-(4-ethynylphenyl)-5-[3,4,5-tris(dodecyloxy)phenyl]-

There total 10 articles about 1,3,4-Oxadiazole, 2-(4-ethynylphenyl)-5-[3,4,5-tris(dodecyloxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-trimethylsilanylethynyl-phenyl)-5-(3,4,5-tris-dodecyloxy-phenyl)-[1,3,4]oxadiazole → 2-(4-ethynylphenyl)-5-(3,4,5-tris-dodecyloxyphenyl)-[1,3,4]oxadiazole (633315-54-5)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h;

DOI:10.1039/b306015b

Reference yield:

4-Bromobenzoic acid (586-76-5) → 2-(4-ethynylphenyl)-5-(3,4,5-tris-dodecyloxyphenyl)-[1,3,4]oxadiazole (633315-54-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride; DMF / CH₂Cl₂ / 2 h / 70 °C

2.1: Et₃N / tetrahydrofuran; CH₂Cl₂ / 0.33 h

3.1: 6.65 g / POCl₃ / 3 h / Heating

4.1: Et₃N / 20 °C

4.2: CuI; PPh₃ / PdCl₂(PPh₃) / 6 h / Heating

5.1: 5.12 g / K₂CO₃ / methanol / 2 h / 20 °C

With thionyl chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/b306015b

Reference yield:

3,4,5-trihydroxybenzoic acid (149-91-7) → 2-(4-ethynylphenyl)-5-(3,4,5-tris-dodecyloxyphenyl)-[1,3,4]oxadiazole (633315-54-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: H₂SO₄ / 3 h / Heating

2.1: KOH; KI / ethanol / Heating

2.2: 38.67 g / ethanol / 6 h / Heating

3.1: KOH / ethanol; H₂O / 3 h / Heating

4.1: thionyl chloride; DMF / CH₂Cl₂ / 2 h / 70 °C

4.2: hydrazine monohydrate; Et₃N / CH₂Cl₂; tetrahydrofuran

5.1: Et₃N / tetrahydrofuran; CH₂Cl₂ / 0.33 h

6.1: 6.65 g / POCl₃ / 3 h / Heating

7.1: Et₃N / 20 °C

7.2: CuI; PPh₃ / PdCl₂(PPh₃) / 6 h / Heating

8.1: 5.12 g / K₂CO₃ / methanol / 2 h / 20 °C

With potassium hydroxide; thionyl chloride; sulfuric acid; potassium carbonate; triethylamine; N,N-dimethyl-formamide; potassium iodide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

DOI:10.1039/b306015b

upstream raw materials:

4-Bromobenzoic acid

3,4,5-trihydroxybenzoic acid

Ethyl gallate

ethyl 3,4,5-tri(dodecyloxy)benzoate