2H-Isoindole-2-propanoic acid, 1,3-dihydro-b-methyl-1,3-dioxo-, 2-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide

Base Information

• Chemical Name: 2H-Isoindole-2-propanoic acid, 1,3-dihydro-b-methyl-1,3-dioxo-, 2-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide
• CAS No.: 63333-73-3
• Molecular Formula: C₂₇H₂₂ClN₅O₃
• Molecular Weight: 499.956
• Mol file: 63333-73-3.mol

Synonyms:

Chemical Property of 2H-Isoindole-2-propanoic acid, 1,3-dihydro-b-methyl-1,3-dioxo-, 2-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Isoindole-2-propanoic acid, 1,3-dihydro-b-methyl-1,3-dioxo-, 2-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide

There total 1 articles about 2H-Isoindole-2-propanoic acid, 1,3-dihydro-b-methyl-1,3-dioxo-, 2-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine (18091-89-9,112393-62-1) + 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)butyric acid (4443-37-2) → 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid N'-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-hydrazide (63333-73-3)

Guidance literature:

With 1,1'-carbonyldiimidazole; Multistep reaction; 1.) THF, RT, 72 min, 2.) THF, RT, 18 h;

DOI:10.1021/jm00178a009

Reference yield:

3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid N'-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-hydrazide (63333-73-3) → N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide (60640-16-6)

Guidance literature:

In acetic acid; at 117 ℃; for 0.7h; Yield given;

DOI:10.1021/jm00178a009

upstream raw materials:

7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)butyric acid

Downstream raw materials:

N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide