5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Base Information

Chemical Name:5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
CAS No.:133627-17-5
Molecular Formula:C14H14N4O
Molecular Weight:254.2872
Hs Code.:2933997500
Mol file:133627-17-5.mol

Synonyms:Dipyridodiazepinone deriv. 2;

Suppliers and Price of 5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
BIRH 414
10mg
$ 502.00

TRC
BIRH414
100mg
$ 1510.00

AvaChem
Nevirapine Impurity A
25mg
$ 575.00

AvaChem
Nevirapine Impurity A
10mg
$ 275.00

AvaChem
Nevirapine Impurity A
5mg
$ 175.00

Total 9 raw suppliers

Chemical Property of 5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Chemical Property:

Melting Point:212-214℃ (1,2-dichloroethane )
Boiling Point:389.8°Cat760mmHg
PKA:12.05±0.20(Predicted)
Flash Point:189.5°C
PSA：61.61000
Density:1.224g/cm³
LogP:2.39330

Purity/Quality:

99%, ^*data from raw suppliers

BIRH 414 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses BIRH 414 is an derivative of 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine, a highly potent inhibitor of wild-type human immunodeficiency virus type 1. BIRH 414 was also shown to exhibit binding affinity towards HIV-1 reverse transcriptase enzyme. This is also an impurity found in Nevirapine (N391275).

Technology Process of 5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

There total 6 articles about 5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23056-39-5
2-chloro-3-nitro-4-methylpyridine

: 133627-17-5
5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / H₂ / 5percent Rh/C / ethanol / 3 h / 2585.7 Torr

2: 65.5 percent / pyridine / cyclohexane; dioxane / 48 h / Ambient temperature

3: xylene / Heating

4: NaH / various solvent(s) / Heating

With pyridine; hydrogen; sodium hydride; Rh on carbon; In 1,4-dioxane; ethanol; cyclohexane; xylene;
DOI:10.1021/jm00111a045