Naveglitazar

Base Information

Chemical Name:Naveglitazar
CAS No.:476436-68-7
Molecular Formula:C25H26O6
Molecular Weight:422.478
Hs Code.:
UNII:Y995M7GM0G
DSSTox Substance ID:DTXSID70870358
Wikidata:Q27294403
NCI Thesaurus Code:C75191
Pharos Ligand ID:T5TT469T61PA
Metabolomics Workbench ID:153608
ChEMBL ID:CHEMBL181954
Mol file:476436-68-7.mol

Synonyms:alpha-methoxy-4-(3-(4-phenoxyphenoxy)propoxy)benzenepropionic acid;LY 519818;LY-519818;LY519818;naveglitazar

Suppliers and Price of Naveglitazar

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Naveglitazar

Chemical Property:

Vapor Pressure:1.23E-14mmHg at 25°C
Boiling Point:587.3°Cat760mmHg
Flash Point:197.7°C
PSA：74.22000
Density:1.198g/cm³
LogP:4.96890
XLogP3:5.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:422.17293854
Heavy Atom Count:31
Complexity:490

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(CC1=CC=C(C=C1)OCCCOC2=CC=C(C=C2)OC3=CC=CC=C3)C(=O)O
Isomeric SMILES:CO[C@@H](CC1=CC=C(C=C1)OCCCOC2=CC=C(C=C2)OC3=CC=CC=C3)C(=O)O
Recent ClinicalTrials:An Evaluation of an Oral Antidiabetic Agent for the Treatment of Type 2 Diabetes
Uses Treatment of Type II diabetes and associated cardiovascular indications.

Technology Process of Naveglitazar

There total 10 articles about Naveglitazar which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 477982-30-2
(S)-2-Methoxy-3-{4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-propionic acid ethyl ester

: 476436-68-7,916085-47-7
Naveglitazar

Guidance literature:: With sodium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2004.10.042

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 476436-68-7,916085-47-7
Naveglitazar

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaN(SiMe₃)2

1.2: (CF₃CO)2O

1.3: H₂ / Pd/C

2.1: cross-linked enzyme crystal; MTBE; KH₂PO₄

2.2: 27 percent / (-)-cinchonidine

3.1: 80 percent / H₂SO₄

4.1: K₂CO₃ / dimethylformamide

5.1: aq. NaOH

With sodium hydroxide; potassium dihydrogenphosphate; tert-butyl methyl ether; cross-linked enzyme crystal; sulfuric acid; sodium hexamethyldisilazane; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.2533/chimia.2006.580

Reference yield:

: 156335-14-7
(S)-methyl 3-(4-hydroxyphenyl)-2-methoxypropanoate

: 476436-68-7,916085-47-7
Naveglitazar

Guidance literature:: Multi-step reaction with 4 steps

1.1: cross-linked enzyme crystal; MTBE; KH₂PO₄

1.2: 27 percent / (-)-cinchonidine

2.1: 80 percent / H₂SO₄

3.1: K₂CO₃ / dimethylformamide

4.1: aq. NaOH

With sodium hydroxide; potassium dihydrogenphosphate; tert-butyl methyl ether; cross-linked enzyme crystal; sulfuric acid; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.2533/chimia.2006.580