1-Pyrrolidineheptanoic acid, 2-[(1E,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4-difluoro-4-phenyl- 1-butenyl]-5-oxo-, 1-methylethyl ester, (2R)-

Base Information

Chemical Name:1-Pyrrolidineheptanoic acid, 2-[(1E,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4-difluoro-4-phenyl- 1-butenyl]-5-oxo-, 1-methylethyl ester, (2R)-
CAS No.:634193-64-9
Molecular Formula:C30H47F2NO4Si
Molecular Weight:551.79
Hs Code.:

1-Pyrrolidineheptanoic acid,
2-[(1E,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4-difluoro-4-phenyl-
1-butenyl]-5-oxo-, 1-methylethyl ester, (2R)-

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Chemical Property of 1-Pyrrolidineheptanoic acid, 2-[(1E,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4-difluoro-4-phenyl- 1-butenyl]-5-oxo-, 1-methylethyl ester, (2R)-

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Technology Process of 1-Pyrrolidineheptanoic acid, 2-[(1E,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4-difluoro-4-phenyl- 1-butenyl]-5-oxo-, 1-methylethyl ester, (2R)-

There total 1 articles about 1-Pyrrolidineheptanoic acid, 2-[(1E,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4-difluoro-4-phenyl- 1-butenyl]-5-oxo-, 1-methylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: isopropyl 7-bromoheptanoate

: 634193-62-7
(5R)-5-((1E,3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-4,4-difluoro-3-4-phenylbut-1-enyl)-1-(4-methoxybenzyl)pyrrolidin-2-one

: 634193-64-9
isopropyl 7-{(2R)-2-[(1E,3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-4,4-difluoro-4-phenylbut-1-enyl]-5-oxopyrrolidin-1-yl}heptanoate

Guidance literature:: (5R)-5-((1E,3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-4,4-difluoro-3-4-phenylbut-1-enyl)-1-(4-methoxybenzyl)pyrrolidin-2-one; With sodium hydride; In DMF (N,N-dimethyl-formamide); H₂₀; at 20 ℃;

isopropyl 7-bromoheptanoate; With sodium iodide; In DMF (N,N-dimethyl-formamide); at 90 ℃; for 6h;