2-Methoxy-[1,1'-biphenyl]-4-amine

Base Information

• Chemical Name: 2-Methoxy-[1,1'-biphenyl]-4-amine
• CAS No.: 56970-24-2
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Hs Code.: 2922299090
• ChEMBL ID: CHEMBL85333
• Mol file: 56970-24-2.mol

Synonyms:2-Methoxy-[1,1'-biphenyl]-4-amine;56970-24-2;3-Methoxy-4-phenylaniline;3-Methoxybiphenylamine;2-methoxybiphenyl-4-amine;4-BIPHENYLAMINE, 3-METHOXY-;3-methoxy4-phenyl aniline;2-methoxy-4-phenyl aniline;2-Methoxybiphenyl-4-ylamine;2-Methoxy-biphenyl-4-ylamine;CHEMBL85333;SCHEMBL2617558;AMY7174;1-amino-3-methoxy-4-phenylbenzene;AC-567;MFCD00198198;AKOS002320031;2-Methoxy-[1,1\'-biphenyl]-4-amine;2-Methoxy[1,1'-biphenyl]-4-amine #;[1,1'-Biphenyl]-4-amine, 2-methoxy-;FT-0694526;2-methoxy-[1,1'-biphenyl]-4-amine, AldrichCPR;A869794;2-methoxy-[1.1-biphenyl]-4-amine

Chemical Property of 2-Methoxy-[1,1'-biphenyl]-4-amine

Chemical Property:

• Vapor Pressure: 0.000411mmHg at 25°C
• Refractive Index: 1.598
• Boiling Point: 316.4 °C at 760 mmHg
• Flash Point: 146.9 °C
• PSA: 35.25000
• Density: 1.1g/cm³
• LogP: 3.52560
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.099714038
• Heavy Atom Count: 15
• Complexity: 189

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-[1,1'-biphenyl]-4-amine 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)N)C2=CC=CC=C2

Technology Process of 2-Methoxy-[1,1'-biphenyl]-4-amine

There total 4 articles about 2-Methoxy-[1,1'-biphenyl]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

→ 2-methoxy-biphenyl-4-ylamine (56970-24-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 16h;

Reference yield: 61.0%

4-bromo-3-methoxyaniline (19056-40-7) + phenylboronic acid (98-80-6) → 2-methoxy-biphenyl-4-ylamine (56970-24-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; for 3.5h; Inert atmosphere;

Reference yield: 51.0%

4-bromo-3-methoxyaniline (19056-40-7) → 2-methoxy-biphenyl-4-ylamine (56970-24-2)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00512

upstream raw materials:

2-methoxy-4-nitrobiphenyl

4-bromo-3-methoxyaniline

phenylboronic acid