7-(2-(Dimethylamino)ethyl)-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

Base Information

Chemical Name:7-(2-(Dimethylamino)ethyl)-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
CAS No.:82946-66-5
Molecular Formula:C₁₅H₁₅NO₂
Molecular Weight:241.29
Hs Code.:
NSC Number:36533
UNII:X7C8RJ9QFC
ChEMBL ID:CHEMBL1742144

Synonyms:NSC36533;NSC-36533;7-(2-(Dimethylamino)ethyl)-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;7-[2-(dimethylamino)ethyl]-8-(hydroxymethyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione;1H-Purine-2,6-dione, 7-(2-(dimethylamino)ethyl)-3,7-dihydro-8-(hydroxymethyl)-1,3-dimethyl-;1H-Purine-2,6-dione, 7-[2-(dimethylamino)ethyl]-3,7-dihydro-8-(hydroxymethyl)-1,3-dimethyl-;X7C8RJ9QFC;NCIStruc1_000576;NCIStruc2_000458;CHEMBL1742144;NCI36533;CCG-38134;NCGC00013422;NSC 365336;NCGC00013422-02;NCGC00096537-01;NCI60_003362;7-(2-(dimethylamino)ethyl)-8-(hydroxymethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;500338-58-9;7-[2-(Dimethylamino)ethyl]-3,7-dihydro-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6-dione

Suppliers and Price of 7-(2-(Dimethylamino)ethyl)-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 7-(2-(Dimethylamino)ethyl)-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

Chemical Property:

Vapor Pressure:6.15E-05mmHg at 25°C
Boiling Point:488.8°Cat760mmHg
Flash Point:249.4°C
Density:1.37g/cm³
XLogP3:-1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:281.14878949
Heavy Atom Count:20
Complexity:403

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)CO)CCN(C)C

Technology Process of 7-(2-(Dimethylamino)ethyl)-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

There total 4 articles about 7-(2-(Dimethylamino)ethyl)-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 618-46-2
m-Chlorobenzoyl chloride

: 82946-66-5
4,4-Dimethyl-2-(11-oxa-tricyclo[6.2.1.0^2,7]undeca-2⁽⁷⁾,3,5,9-tetraen-3-yl)-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 14 h / Ambient temperature

2: 70 percent / thionyl chloride / benzene; CH₂Cl₂ / 1.) reflux, 2.) room temperature, 2.5 h

3: 1.) n-butyllithium / 1.) THF/hexane, -78 deg C, 30 min, 2.) THF/hexane, -15 deg C, 5 h

With n-butyllithium; thionyl chloride; In dichloromethane; benzene;
DOI:10.1021/ja00229a037

Reference yield:

: 701923-86-6
3-Chloro-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide

: 82946-66-5
4,4-Dimethyl-2-(11-oxa-tricyclo[6.2.1.0^2,7]undeca-2⁽⁷⁾,3,5,9-tetraen-3-yl)-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / thionyl chloride / benzene; CH₂Cl₂ / 1.) reflux, 2.) room temperature, 2.5 h

2: 1.) n-butyllithium / 1.) THF/hexane, -78 deg C, 30 min, 2.) THF/hexane, -15 deg C, 5 h

With n-butyllithium; thionyl chloride; In dichloromethane; benzene;
DOI:10.1021/ja00229a037

Reference yield:

: 535-80-8
3-chlorobenzoate

: 82946-66-5
4,4-Dimethyl-2-(11-oxa-tricyclo[6.2.1.0^2,7]undeca-2⁽⁷⁾,3,5,9-tetraen-3-yl)-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 1 h / 100 °C

2: CH₂Cl₂ / 14 h / Ambient temperature

3: 70 percent / thionyl chloride / benzene; CH₂Cl₂ / 1.) reflux, 2.) room temperature, 2.5 h

4: 1.) n-butyllithium / 1.) THF/hexane, -78 deg C, 30 min, 2.) THF/hexane, -15 deg C, 5 h

With n-butyllithium; thionyl chloride; In dichloromethane; benzene;
DOI:10.1021/ja00229a037