3-Hydroxyphenazepam

Base Information

Chemical Name:3-Hydroxyphenazepam
CAS No.:70030-11-4
Molecular Formula:C15H10 Br Cl N2 O2
Molecular Weight:365.614
Hs Code.:
UNII:1KJ8MP77JK
DSSTox Substance ID:DTXSID10990281
Nikkaji Number:J1.074.642F
Wikipedia:3-Hydroxyphenazepam
Wikidata:Q18589010
ChEMBL ID:CHEMBL1449427
Mol file:70030-11-4.mol

Synonyms:3-hydroxyphenazepam;3-oxyfenazepam

Suppliers and Price of 3-Hydroxyphenazepam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
3-Hydroxyphenazepam
10 mg
$ 825.00

Medical Isotopes, Inc.
3-Hydroxyphenazepam
2.5 mg
$ 650.00

Cayman Chemical
3-hydroxy Phenazepam ≥98%
1mg
$ 44.00

Cayman Chemical
3-hydroxy Phenazepam ≥98%
10mg
$ 352.00

Cayman Chemical
3-hydroxy Phenazepam ≥98%
5mg
$ 198.00

AK Scientific
3-Hydroxyphenazepam
1mg
$ 159.00

Total 62 raw suppliers

Chemical Property of 3-Hydroxyphenazepam

Chemical Property:

Vapor Pressure:1.09E-12mmHg at 25°C
Boiling Point:544.5°C at 760 mmHg
Flash Point:283.1°C
PSA：65.18000
Density:1.7g/cm³
LogP:2.73110
Storage Temp.:refrigerate for prolonged storage
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:363.96142
Heavy Atom Count:21
Complexity:445

Purity/Quality:

99%, ^*data from raw suppliers

3-Hydroxyphenazepam ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Br)O)Cl
Description 3-Hydroxyphenazepam is an active metabolite of the novel psychoactive benzodiazepine phenazepam, which emerged in online drug markets in late 2011. Despite being a controlled substance in Europe, North America, and many countries in Asia, phenazepam has been encountered in the form of LSD mimic blotters and as counterfeit diazepam. This certified Snap-N-Spike(R) solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.
Uses 3-Hydroxyphenazepam, a metabolite of phenazepam, is also a GABAA receptor agonist. It has diminished myorelaxant properties, but is about equivalent in most other regards.Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an EC50 value of 10.3 nM. 3-hydroxyphenazepam is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.

Technology Process of 3-Hydroxyphenazepam

There total 3 articles about 3-Hydroxyphenazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 51753-57-2
phenazepam

: 70030-11-4
3-hydroxy-7-bromo-5-(2'-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one

Guidance literature:: With ammonium sulfate; corn steep; D-glucose; iron(II) sulfate; calcium carbonate; sodium chloride; starch; at 28 ℃; pH 6.8-7.0, microbiological transformation by actinomycetes;