Tbpb

Base Information

Chemical Name:Tbpb
CAS No.:634616-95-8
Molecular Formula:C25H32N4O
Molecular Weight:404.555
Hs Code.:
European Community (EC) Number:804-126-4
ChEMBL ID:CHEMBL522460
Pharos Ligand ID:YGKPRGJ74C8M
Wikidata:Q27088942
Mol file:634616-95-8.mol

Synonyms:TBPB;634616-95-8;1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;CHEMBL522460;3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one;2-Pyrrolo-1,3,2-dioxa-phospholan;GTPL3258;SCHEMBL5473311;CWPKTBMRVATCBL-UHFFFAOYSA-N;BCP13406;TBPB, >=98% (HPLC);BDBM50263887;AKOS026750197;2-pyrrol-1-yl-1,3,2-dioxaphospholan;CS-3517;NCGC00390669-01;HY-14562;MS-26922;FT-0746315;F85081;A918055;BRD-K86989957-001-01-7;Q27088942;1,3-Dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one;1-(1''-(2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;1-(1''-2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;1-(1a?(2-Methylbenzyl)-1,4a?bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;1-[1-[1-(2-Methylbenzyl)piperidin-4-yl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one

Suppliers and Price of Tbpb

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TBPB
5mg
$ 85.00

Sigma-Aldrich
TBPB ≥98% (HPLC)
5mg
$ 102.00

Sigma-Aldrich
TBPB ≥98% (HPLC)
25mg
$ 396.00

Medical Isotopes, Inc.
TBPB
10 mg
$ 650.00

Matrix Scientific
1-(1'-(2-Methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one 95%
5g
$ 8525.00

Matrix Scientific
1-(1'-(2-Methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one 95%
1g
$ 2664.00

DC Chemicals
TBPB >98%
250 mg
$ 850.00

Crysdot
TBPB 98+%
50mg
$ 294.00

Crysdot
TBPB 98+%
10mg
$ 70.00

Crysdot
TBPB 98+%
5mg
$ 42.00

Total 10 raw suppliers

Chemical Property of Tbpb

Chemical Property:

PKA:12.04±0.30(Predicted)
PSA：44.53000
Density:1.193±0.06 g/cm3(Predicted)
LogP:4.22760
Storage Temp.:2-8°C
Solubility.:DMSO: soluble5mg/mL (clear solution; warmed)
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:404.25761166
Heavy Atom Count:30
Complexity:582

Purity/Quality:

99%, ^*data from raw suppliers

TBPB ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=CC=CC=C5NC4=O
Uses TBPB is an allosteric M1 muscarinic acetylcholine receptor activator that regulates amyloid processing and produces antipsychotic-like activity in rats.

Technology Process of Tbpb

There total 5 articles about Tbpb which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1074762-36-9
1-(2-methylbenzyl)piperidin-4,4-diol

: 20662-53-7
4-(2-keto-1-benzimidazolinyl)piperidine

: 634616-95-8
TBPB

Guidance literature:: With MP-triacetoxyborohydride; In dichloromethane;
DOI:10.1016/j.bmcl.2008.09.023

Reference yield: 78.0%

: 20662-53-7
4-(2-keto-1-benzimidazolinyl)piperidine

: 76167-41-4
1-(2-Methylbenzyl)-4-piperidone

: 634616-95-8
TBPB

Guidance literature:: 4-(2-keto-1-benzimidazolinyl)piperidine; 1-(2-Methylbenzyl)-4-piperidone; With acetic acid; In dichloromethane; at 0 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1080/00397911.2012.670740

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 634616-95-8
TBPB

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane / 0.25 h / 0 °C

1.2: 16 h / 0 - 20 °C

2.1: dichloromethane / 0.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

4.1: acetic acid / dichloromethane / 1 h / 0 °C

4.2: 16 h / 0 - 20 °C

With acetic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1080/00397911.2012.670740