2-(6,10-dimethyl-2-spiro[4.5]dec-9-enyl)propan-2-ol

Base Information

Chemical Name:2-(6,10-dimethyl-2-spiro[4.5]dec-9-enyl)propan-2-ol
CAS No.:1460-73-7
Molecular Formula:C15H26 O
Molecular Weight:222.371
Hs Code.:
Mol file:1460-73-7.mol

Synonyms:Spiro[4.5]dec-6-ene-2-methanol,a,a,6,10-tetramethyl- (7CI,8CI);Spiro[4.5]dec-6-ene-2-methanol, a,a,6,10-tetramethyl-, [2R-[2a,5b(R*)]]-; (-)-Agarospirol; Agarospirol

Suppliers and Price of 2-(6,10-dimethyl-2-spiro[4.5]dec-9-enyl)propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 27 raw suppliers

Chemical Property of 2-(6,10-dimethyl-2-spiro[4.5]dec-9-enyl)propan-2-ol

Chemical Property:

Vapor Pressure:4.73E-05mmHg at 25°C
Boiling Point:312.2°Cat760mmHg
PKA:15.14±0.29(Predicted)
Flash Point:114.6°C
PSA：20.23000
Density:0.96g/cm³
LogP:3.92000

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(6,10-dimethyl-2-spiro[4.5]dec-9-enyl)propan-2-ol

There total 165 articles about 2-(6,10-dimethyl-2-spiro[4.5]dec-9-enyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Agarospirol-acetat

: 1460-73-7,26934-83-8,4895-33-4
2-[(3R,5R,6R)-6,10-dimethylspiro[4.5]dec-9-en-3-yl]propan-2-ol

Guidance literature:: With potassium hydroxide; In ethanol;
DOI:10.1016/S0040-4020(01)82208-0

Reference yield:

: 928203-24-1
2-propenyl-2,3,6,7-tetrahydro-5H-cyclopenta[b]pyran-4-one

: 1460-73-7,26934-83-8,4895-33-4
2-[(3R,5R,6R)-6,10-dimethylspiro[4.5]dec-9-en-3-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: LiAlH₄

1.2: imidazole

2.1: 73 percent / toluene / 4.17 h / 250 °C

3.1: 96 percent / H₂; [Ir(cod)(Pcy₃)py]PF₆ / CH₂Cl₂ / 760 Torr

4.1: 98 percent / HF

5.1: 95 percent / Dess-Martin periodinane

6.1: H₂; [Ir(cod)(Pcy₃)py]PF₆ / CH₂Cl₂ / 760 Torr

7.1: TiCl₄; Zn

8.1: TsOH*H₂O / benzene / Heating

9.1: diethyl ether

With lithium aluminium tetrahydride; Crabtree's catalyst; hydrogen fluoride; hydrogen; titanium tetrachloride; Dess-Martin periodane; toluene-4-sulfonic acid; zinc; In diethyl ether; dichloromethane; toluene; benzene; 2.1: Claisen rearrangement;
DOI:10.1246/cl.2007.42

Reference yield:

: 928203-23-0
2-(3-hydroxy-hex-4-enoyl)-cyclopentanone

: 1460-73-7,26934-83-8,4895-33-4
2-[(3R,5R,6R)-6,10-dimethylspiro[4.5]dec-9-en-3-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 11 steps

1.1: 76 percent / TsOH*H₂O / CH₂Cl₂ / 20 °C

2.1: LiAlH₄

2.2: imidazole

3.1: 73 percent / toluene / 4.17 h / 250 °C

4.1: 96 percent / H₂; [Ir(cod)(Pcy₃)py]PF₆ / CH₂Cl₂ / 760 Torr

5.1: 98 percent / HF

6.1: 95 percent / Dess-Martin periodinane

7.1: H₂; [Ir(cod)(Pcy₃)py]PF₆ / CH₂Cl₂ / 760 Torr

8.1: TiCl₄; Zn

9.1: TsOH*H₂O / benzene / Heating

10.1: diethyl ether

With lithium aluminium tetrahydride; Crabtree's catalyst; hydrogen fluoride; hydrogen; titanium tetrachloride; Dess-Martin periodane; toluene-4-sulfonic acid; zinc; In diethyl ether; dichloromethane; toluene; benzene; 3.1: Claisen rearrangement;
DOI:10.1246/cl.2007.42