Typhasterol

Base Information

Chemical Name:Typhasterol
CAS No.:87734-68-7
Molecular Formula:C₂₈H₄₈O₄
Molecular Weight:448.687
Hs Code.:
UNII:GG2V86UZ00
DSSTox Substance ID:DTXSID5041146
Metabolomics Workbench ID:34793
Nikkaji Number:J146.606B
Wikidata:Q27109939
Mol file:87734-68-7.mol

Synonyms:Typhasterol;2-Deoxycastasterone;87734-68-7;GG2V86UZ00;UNII-GG2V86UZ00;6-oxo-Campestan-3alpha,22R,23R-triol;(3R,5S,8S,9S,10R,13S,14S,17R)-17-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-3-hydroxy-10,13-dimethyl-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one;(3alpha,5alpha,22R,23R,24S)-3,22,23-trihydroxyergostan-6-one;Ergostan-6-one, 3,22,23-trihydroxy-, (3alpha,5alpha,22R,23R,24S)-;SCHEMBL1401892;DTXSID5041146;CHEBI:27173;LMST01030130;Q27109939;ERGOSTAN-6-ONE, 3,22,23-TRIHYDROXY-, (3.ALPHA.,5.ALPHA.,22R,23R,24S)-

Suppliers and Price of Typhasterol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Typhasterol
25mg
$ 20625.00

Total 3 raw suppliers

Chemical Property of Typhasterol

Chemical Property:

Melting Point:138 °C
Boiling Point:133-134 °C
PKA:14.29±0.20(Predicted)
PSA：77.76000
Density:1.080±0.06 g/cm3(Predicted)
LogP:4.83520
XLogP3:5.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:448.35526001
Heavy Atom Count:32
Complexity:706

Purity/Quality:: Typhasterol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C)C(C(C(C)C1CCC2C1(CCC3C2CC(=O)C4C3(CCC(C4)O)C)C)O)O
Isomeric SMILES:C[C@@H]([C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC(=O)[C@@H]4[C@@]3(CC[C@H](C4)O)C)C)[C@H]([C@@H]([C@@H](C)C(C)C)O)O
Uses Typhasterol can be used in biological study for role of plant steroid hormones produced under Ni stress in regulation of metal uptake and oxidative stress in Brassica juncea L.

Technology Process of Typhasterol

There total 53 articles about Typhasterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103382-92-9
3α,6α-diacetoxy-5β-pregnane-20-carbaldehyde

: 87734-68-7
typhasterol

Guidance literature:: Multi-step reaction with 8 steps

1: 72 percent / tetrahydrofuran / 24 h / Ambient temperature

2: 86 percent / 1.) H₂O₂, 4 M NaOH; 2.) Ac₂O, pyridine / ethanol / 1.) 35 deg C, 4 h

3: 1.) NaH; 2.) Ac₂O, pyridine / 1.) THF, rt., 2 h

4: 30percent HClO₄ / methanol / 0.17 h / Ambient temperature

5: pyridinium dichromate / CH₂Cl₂ / 5 h / Ambient temperature

6: hydrogen / PtO₂ / ethanol; ethyl acetate / Ambient temperature

7: 1.) di-isobutylaluminum hydride; 2.) p-TsOH; 3.) tris-(triphenylphosphine) rhodium chloride / 1.) toluene, -78 deg C, 1 h; 2.) 2,2-dimethoxypropane; 3.) toluene, reflux

8: 1.) pyridinium dichromate; 2.) 5percent HCl / 1.) CH₂Cl₂; 2.) MeOH

With pyridine; hydrogenchloride; sodium hydroxide; Wilkinson's catalyst; dipyridinium dichromate; perchloric acid; diisobutylaluminum hydride; hydrogen; dihydrogen peroxide; acetic anhydride; sodium hydride; toluene-4-sulfonic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1039/c39890000612

Reference yield:

: 124853-23-2
(22S,23R)-3α,6α-diacetoxy-22,23-epoxy-5β-cholestan-24-one

: 87734-68-7
typhasterol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH; 2.) Ac₂O, pyridine / 1.) THF, rt., 2 h

2: 30percent HClO₄ / methanol / 0.17 h / Ambient temperature

3: pyridinium dichromate / CH₂Cl₂ / 5 h / Ambient temperature

4: hydrogen / PtO₂ / ethanol; ethyl acetate / Ambient temperature

5: 1.) di-isobutylaluminum hydride; 2.) p-TsOH; 3.) tris-(triphenylphosphine) rhodium chloride / 1.) toluene, -78 deg C, 1 h; 2.) 2,2-dimethoxypropane; 3.) toluene, reflux

6: 1.) pyridinium dichromate; 2.) 5percent HCl / 1.) CH₂Cl₂; 2.) MeOH

With pyridine; hydrogenchloride; Wilkinson's catalyst; dipyridinium dichromate; perchloric acid; diisobutylaluminum hydride; hydrogen; acetic anhydride; sodium hydride; toluene-4-sulfonic acid; platinum(IV) oxide; In methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1039/c39890000612

Reference yield:

: 124853-25-4
Δ²⁴⁽²⁸⁾-(22R)-3α,6α-diacetoxy-24-carboxyethylene-23-oxo-5β-cholesten-22(29)-lactone

: 87734-68-7
typhasterol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / PtO₂ / ethanol; ethyl acetate / Ambient temperature

2: 1.) di-isobutylaluminum hydride; 2.) p-TsOH; 3.) tris-(triphenylphosphine) rhodium chloride / 1.) toluene, -78 deg C, 1 h; 2.) 2,2-dimethoxypropane; 3.) toluene, reflux

3: 1.) pyridinium dichromate; 2.) 5percent HCl / 1.) CH₂Cl₂; 2.) MeOH

With hydrogenchloride; Wilkinson's catalyst; dipyridinium dichromate; diisobutylaluminum hydride; hydrogen; toluene-4-sulfonic acid; platinum(IV) oxide; In ethanol; ethyl acetate;
DOI:10.1039/c39890000612