Calcium dobesilate

Base Information

• Chemical Name: Calcium dobesilate
• CAS No.: 20123-80-2
• Molecular Formula: C12H10Ca2O10S2
• Molecular Weight: 418.415
• Hs Code.: 2924299090
• European Community (EC) Number: 243-531-5
• UNII: 5921X1560Q
• DSSTox Substance ID: DTXSID60173946
• Wikipedia: Calcium_dobesilate
• Wikidata: Q5018825
• NCI Thesaurus Code: C166829
• RXCUI: 1904
• ChEMBL ID: CHEMBL2106191
• Mol file: 20123-80-2.mol

Synonyms:2,5 Dihydroxybenzenesulfonate;2,5 Dihydroxybenzenesulfonic Acid;2,5-Dihydroxybenzenesulfonate;2,5-Dihydroxybenzenesulfonic Acid;Calcium Dobesilate;Calcium Dobesilate (1:1);Calcium Dobesilate Monoammonium Salt;Calcium Dobesilate Monopotassium Salt;Calcium, Dobesilate;Dexium;Dobesilate Calcium;Dobesilate, Calcium;Dobica;Doxium

Chemical Property of Calcium dobesilate

Chemical Property:

• Appearance/Colour: white or almost powder
• Melting Point: >300° (dec)
• PSA: 212.08000
• LogP: 2.16540
• Storage Temp.: room temp
• Solubility.: H2O: soluble15mg/mL, clear
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 0
• Exact Mass: 417.9341297
• Heavy Atom Count: 25
• Complexity: 228

Purity/Quality:

99% ^*data from raw suppliers

Dobesilate Calcium ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1O)S(=O)(=O)[O-])O.C1=CC(=C(C=C1O)S(=O)(=O)[O-])O.[Ca+2]
• Recent ClinicalTrials: Effect of HMP on Diabetic Microangiopaemia in T2DM
• Recent EU Clinical Trials: Effect of calcium dobesilate in early stages of diabetic retinopathy
• Description: Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.
• Uses: Calcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide. Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.
• Indications: Calcium dobesilate (CaD) is a widely prescribed veno-tonic drug for CVI, diabetic retinopathy, and the symptoms of hemorrhoid attacks.Calcium dobesilate is also almost the only one angioprotective drug that recently remains the object of interest in treatment of diabetic retinopathy including clinical studies (Leal et al. 2010, Einarsdottir & Stefansson, 2009, Ribeiro et al., 2006), and even it was used as a standard for determination of the particular activity of a traditional Chinese herbal medicine preparation (Luo et al. 2009).
• Therapeutic Function: Vasodilator

Technology Process of Calcium dobesilate

There total 2 articles about Calcium dobesilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dobesilate (88-46-0) → calcium dobesilate (20123-80-2)

Guidance literature:

With sulfuric acid; calcium carbonate; In water; at 20 ℃; for 0.25h;

DOI:10.2298/JSC131128032F

Reference yield:

hydroquinone (123-31-9,8027-02-9) → calcium dobesilate (20123-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / water / 1 h / 45 °C

2: sulfuric acid; calcium carbonate / water / 0.25 h / 20 °C

With sulfuric acid; calcium carbonate; In water;

DOI:10.2298/JSC131128032F

Reference yield:

calcium dobesilate (20123-80-2) → magnesium 2,5-dihydroxybenzenesulfonate

Guidance literature:

With magnesium sulfate; at 20 ℃; for 0.5h;

DOI:10.2298/JSC131128032F

upstream raw materials:

hydroquinone

dobesilate