Spiro(5H-dibenzo(a,d)cycloheptene-5,4'-imidazolidine)-2',5'-dione, 10,11-dihydro-

Base Information

Chemical Name:Spiro(5H-dibenzo(a,d)cycloheptene-5,4'-imidazolidine)-2',5'-dione, 10,11-dihydro-
CAS No.:64036-58-4
Molecular Formula:C₁₇H₁₄N₂O₂
Molecular Weight:278.31
Hs Code.:2933990090
DSSTox Substance ID:DTXSID50214019
Nikkaji Number:J87.089G
Mol file:64036-58-4.mol

Synonyms:64036-58-4;Spiro(5H-dibenzo(a,d)cycloheptene-5,4'-imidazolidine)-2',5'-dione, 10,11-dihydro-;BRN 0758398;Spiro(dibenzo(a,d)cycloheptadiene-5,4'-imidazolidine)-2',5'-dione;DTXSID50214019

Suppliers and Price of Spiro(5H-dibenzo(a,d)cycloheptene-5,4'-imidazolidine)-2',5'-dione, 10,11-dihydro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Spiro(5H-dibenzo(a,d)cycloheptene-5,4'-imidazolidine)-2',5'-dione, 10,11-dihydro-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：65.18000
Density:1.36g/cm³
LogP:1.78410
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:278.105527694
Heavy Atom Count:21
Complexity:438

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=CC=CC=C2C3(C4=CC=CC=C41)C(=O)NC(=O)N3

Technology Process of Spiro(5H-dibenzo(a,d)cycloheptene-5,4'-imidazolidine)-2',5'-dione, 10,11-dihydro-

There total 8 articles about Spiro(5H-dibenzo(a,d)cycloheptene-5,4'-imidazolidine)-2',5'-dione, 10,11-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 308086-49-9
1-{5-Carbomethoxy-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5}urea

: 64036-58-4
Spiro{10,11-dihydro-9H-dibenzo[a,d]cycloheptene-9,5'-imidiazolidine}-N'-2',4'-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; Heating;
DOI:10.1055/s-2000-7108

Reference yield:

: 1210-35-1
10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one

: 64036-58-4
Spiro{10,11-dihydro-9H-dibenzo[a,d]cycloheptene-9,5'-imidiazolidine}-N'-2',4'-dione

Guidance literature:: Multi-step reaction with 7 steps

1: Na / 1,2-dimethoxy-ethane / 20 °C

2: 1,2-dimethoxy-ethane / 24 h / 20 °C

3: 98 percent / NaN₃; trifluoroacetic acid / CH₂Cl₂ / 48 h / 20 °C

4: 73 percent / Zn / acetic acid / 24 h / 20 °C

5: Et₃N / tetrahydrofuran / 0.33 h / 20 °C

6: NH₃ / tetrahydrofuran / 0.5 h

7: 82 percent / NaH / tetrahydrofuran / Heating

With sodium azide; ammonia; sodium; sodium hydride; triethylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; acetic acid; 1: Reduction / 2: Substitution / 3: Substitution / 4: Reduction / 5: Acylation / 6: Addition / 7: Cyclization;
DOI:10.1055/s-2000-7108

Reference yield:

: 10541-20-5
Methyl 10,11-dihydro-5-hydroxydibenzo[a,d]cycloheptene-5-carboxylate

: 64036-58-4
Spiro{10,11-dihydro-9H-dibenzo[a,d]cycloheptene-9,5'-imidiazolidine}-N'-2',4'-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / NaN₃; trifluoroacetic acid / CH₂Cl₂ / 48 h / 20 °C

2: 73 percent / Zn / acetic acid / 24 h / 20 °C

3: Et₃N / tetrahydrofuran / 0.33 h / 20 °C

4: NH₃ / tetrahydrofuran / 0.5 h

5: 82 percent / NaH / tetrahydrofuran / Heating

With sodium azide; ammonia; sodium hydride; triethylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; acetic acid; 1: Substitution / 2: Reduction / 3: Acylation / 4: Addition / 5: Cyclization;
DOI:10.1055/s-2000-7108