Methyl 3-amino-4-chloro-5-methoxybenzenecarboxylate

Base Information

• Chemical Name: Methyl 3-amino-4-chloro-5-methoxybenzenecarboxylate
• CAS No.: 63603-10-1
• Molecular Formula: C9H10ClNO3
• Molecular Weight: 215.636
• Hs Code.: 2922509090

Synonyms:methyl 4-chloro-3-methoxy-5-aminobenzoate;

Chemical Property of Methyl 3-amino-4-chloro-5-methoxybenzenecarboxylate

Chemical Property:

• Boiling Point: 341.6±37.0 °C(Predicted)
• PKA: 1.09±0.10(Predicted)
• PSA: 90.58000
• Density: 1.302±0.06 g/cm3(Predicted)
• LogP: 3.49220

Purity/Quality:

97% ^*data from raw suppliers

Methyl 3-amino-4-chloro-5-methoxybenzoate 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-amino-4-chloro-5-methoxybenzenecarboxylate

There total 4 articles about Methyl 3-amino-4-chloro-5-methoxybenzenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 4-chloro-3-methoxy-5-nitrobenzoate (63603-09-8) → methyl 4-chloro-3-methoxy-5-aminobenzoate (63603-10-1)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; at 70 ℃; for 3h; Inert atmosphere;

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → methyl 4-chloro-3-methoxy-5-aminobenzoate (63603-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / dichloromethane; water / 2.5 h / -60 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / 0 - 80 °C

3: hydrogenchloride / iron / ethanol; water / 3 h / 70 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; nitric acid; iron; N,N-dimethyl-formamide; In ethanol; dichloromethane; water;

Reference yield:

4-hydroxy-3-methoxy-5-nitrobenzoic acid methyl ester (42590-00-1) → methyl 4-chloro-3-methoxy-5-aminobenzoate (63603-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 0 - 80 °C

2: hydrogenchloride / iron / ethanol; water / 3 h / 70 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; iron; N,N-dimethyl-formamide; In ethanol; water;

upstream raw materials:

methyl 4-chloro-3-methoxy-5-nitrobenzoate

4-hydroxy-3-methoxybenzoic acid methyl ester

4-hydroxy-3-methoxy-5-nitrobenzoic acid methyl ester

Downstream raw materials:

3-amino-4-chloro-5-hydroxybenzoic acid hydrobromide

methyl 3-(bis(tert-butoxycarbonyl)amino)-4-chloro-5-methoxybenzoate

3,4-Dichloro-5-hydroxybenzoic acid

methyl 3,4-dichloro-5-methoxybenzoate

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