Technology Process of 1,3-Benzenedicarboxamide,
N'-[(1S,2S,4R)-2-azido-5-hydroxy-4-methyl-1-(phenylmethyl)pentyl]-N,N
-dipropyl-
There total 10 articles about 1,3-Benzenedicarboxamide,
N'-[(1S,2S,4R)-2-azido-5-hydroxy-4-methyl-1-(phenylmethyl)pentyl]-N,N
-dipropyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 8h;
DOI:10.1021/jm0509142
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 99 percent / H2 / Pd/C / tetrahydrofuran / 5 h
2: 76 percent / LiAlH4 / tetrahydrofuran; 1,2-dimethoxy-ethane / 0 - 20 °C
3: 98 percent / imidazole / CH2Cl2 / 1 h / 0 °C
4: 95 percent / triethylamine / CHCl3 / 1 h / 0 °C
5: 60 percent / NaN3 / dimethylformamide / 8 h / 60 °C
6: HCl / dioxane / 1 h
7: 113 mg / diisopropylethylamine; HOBt; EDC / dimethylformamide / 8 h / 20 °C
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0509142
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 58 percent / NaBH4 / methanol / -78 - -15 °C
2: 99 percent / H2 / Pd/C / tetrahydrofuran / 5 h
3: 76 percent / LiAlH4 / tetrahydrofuran; 1,2-dimethoxy-ethane / 0 - 20 °C
4: 98 percent / imidazole / CH2Cl2 / 1 h / 0 °C
5: 95 percent / triethylamine / CHCl3 / 1 h / 0 °C
6: 60 percent / NaN3 / dimethylformamide / 8 h / 60 °C
7: HCl / dioxane / 1 h
8: 113 mg / diisopropylethylamine; HOBt; EDC / dimethylformamide / 8 h / 20 °C
With
1H-imidazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0509142
