20-Deoxo-4'-deoxycirramycin A1

Base Information

Chemical Name:20-Deoxo-4'-deoxycirramycin A1
CAS No.:59227-84-8
Molecular Formula:C31H53NO8
Molecular Weight:567.75
Hs Code.:
Mol file:59227-84-8.mol

Synonyms:(E)-(1S,2R,3R,7R,8S,9S,10S,12R,16S)-9-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-3,10-diethyl-7-hydroxy-2,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadec-14-ene-5,13-dione;20-deoxo-20-dihydrorosaramicin;

Suppliers and Price of 20-Deoxo-4'-deoxycirramycin A1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 20-Deoxo-4'-deoxycirramycin A1

Chemical Property:

PSA：118.06000
LogP:3.49140

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 20-Deoxo-4'-deoxycirramycin A1

There total 22 articles about 20-Deoxo-4'-deoxycirramycin A1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.3%

: 59227-83-7
12,13-de-epoxy-12,13-didehydro-20-deoxorosaramicin

: 59227-84-8
20-deoxo-20-dihydrorosaramicin

Guidance literature:: With JuvD-RhFRED; In water; at 30 ℃; Enzymatic reaction;
DOI:10.1021/jacs.7b02875

Reference yield:

: 1403991-96-7
(S)-4-benzyl-3-((4S,5R,E)-5-(tert-butyldimethylsilyloxy)-2,4-dimethylhept-2-enoyl)oxazolidin-2-one

: 59227-84-8
20-deoxo-20-dihydrorosaramicin

Guidance literature:: Multi-step reaction with 8 steps

1: lithium borohydride; methanol / tetrahydrofuran / 1.5 h / 0 - 20 °C

2: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3: caesium carbonate / isopropyl alcohol / 24 h / 0 - 20 °C

4: Divinyl sulfone; tributylphosphine / dichloromethane / 0.5 h / 0 °C

5: hydrogen fluoride / acetonitrile; water / 35 h / -20 °C / Darkness

6: nicotinamide adenine dinucleotide phosphate; glucose-6-phosphate; glucose-6-phosphate dehydrogenase / aq. phosphate buffer; water / 2.3 h / 30 °C / pH 7.2 / Enzymatic reaction

7: acetyl-narbonolide / water; dimethyl sulfoxide / 24 h / 28 °C / Enzymatic reaction

8: JuvD-RhFRED / water / 30 °C / Enzymatic reaction

With Divinyl sulfone; methanol; lithium borohydride; glucose-6-phosphate dehydrogenase; glucose-6-phosphate; tributylphosphine; nicotinamide adenine dinucleotide phosphate; hydrogen fluoride; sodium hydrogencarbonate; caesium carbonate; Dess-Martin periodane; In tetrahydrofuran; aq. phosphate buffer; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile; 3: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jacs.7b02875

Reference yield:

: (E,4S,5R)-5-tert-butyldimethylsilyloxy-2,4-dimethylhept-2-ene-1-ol

: 59227-84-8
20-deoxo-20-dihydrorosaramicin

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2: caesium carbonate / isopropyl alcohol / 24 h / 0 - 20 °C

3: Divinyl sulfone; tributylphosphine / dichloromethane / 0.5 h / 0 °C

4: hydrogen fluoride / acetonitrile; water / 35 h / -20 °C / Darkness

5: nicotinamide adenine dinucleotide phosphate; glucose-6-phosphate; glucose-6-phosphate dehydrogenase / aq. phosphate buffer; water / 2.3 h / 30 °C / pH 7.2 / Enzymatic reaction

6: acetyl-narbonolide / water; dimethyl sulfoxide / 24 h / 28 °C / Enzymatic reaction

7: JuvD-RhFRED / water / 30 °C / Enzymatic reaction

With Divinyl sulfone; glucose-6-phosphate dehydrogenase; glucose-6-phosphate; tributylphosphine; nicotinamide adenine dinucleotide phosphate; hydrogen fluoride; sodium hydrogencarbonate; caesium carbonate; Dess-Martin periodane; In aq. phosphate buffer; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile; 2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jacs.7b02875