5-Chloroimidazo[1,2-A]pyrazine

Base Information

• Chemical Name: 5-Chloroimidazo[1,2-A]pyrazine
• CAS No.: 63744-41-2
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.56900
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50511232
• Wikidata: Q72452067
• Mol file: 63744-41-2.mol

Synonyms:5-CHLOROIMIDAZO[1,2-A]PYRAZINE;63744-41-2;Imidazo[1,2-a]pyrazine, 5-chloro-;5-chloro-Imidazo[1,2-a]pyrazine;SCHEMBL3231277;DTXSID50511232;ORPGZTZXVOKJHD-UHFFFAOYSA-N;MFCD13193447;AKOS016001262;AM101062;AS-36497;CS-0067960;FT-0692705;EN300-304845;J-517392

Chemical Property of 5-Chloroimidazo[1,2-A]pyrazine

Chemical Property:

• Melting Point: 95.0-95.5 °C
• PKA: 2.71±0.30(Predicted)
• PSA: 30.19000
• Density: 1.514g/cm3
• LogP: 1.38270
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 153.0093748
• Heavy Atom Count: 10
• Complexity: 130

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Chloroimidazo[1,2-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C(=CN=CC2=N1)Cl

Technology Process of 5-Chloroimidazo[1,2-A]pyrazine

There total 3 articles about 5-Chloroimidazo[1,2-A]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-chloroethanal (107-20-0) + 2-amino-6-chloropyrazine (33332-28-4) → 5-chloro-imidazo[1,2-a]pyrazine (63744-41-2)

Guidance literature:

In 1,2-dimethoxyethane; water; at 60 ℃; for 1.5h;

Reference yield: 25.31%

1-bromo-2,2-dimethoxyethane (7252-83-7) + 2-amino-6-chloropyrazine (33332-28-4) → 5-chloro-imidazo[1,2-a]pyrazine (63744-41-2)

Guidance literature:

With hydrogen bromide; sodium hydrogencarbonate; In isopropyl alcohol; Reflux;

Reference yield:

→ 5-chloro-imidazo[1,2-a]pyrazine (63744-41-2)

Guidance literature:

Bromacetal, 2-Amino-6-chlorpyrazin;

DOI:10.1021/jo00862a005

upstream raw materials:

1-bromo-2,2-dimethoxyethane

2-amino-6-chloropyrazine

2-chloroethanal

Refernces

• 1、 -. "SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS". Page/Page column 106; 107. . Retrieved 2012/02/13.
• 2、 -. "1, 3-DISUBSTITUTED IMIDAZOLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF CYP 17". Page/Page column 196-197. . Retrieved 2011/01/12.