5-Morpholino-2-thiophenecarbaldehyde

Base Information

• Chemical Name: 5-Morpholino-2-thiophenecarbaldehyde
• CAS No.: 24372-49-4
• Molecular Formula: C9H11NO2S
• Molecular Weight: 197.258
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10368108
• Nikkaji Number: J948.315B
• Wikidata: Q82154438
• Mol file: 24372-49-4.mol

Synonyms:24372-49-4;5-Morpholino-2-thiophenecarbaldehyde;5-morpholinothiophene-2-carbaldehyde;5-morpholin-4-ylthiophene-2-carbaldehyde;5-Morpholin-4-yl-thiophene-2-carbaldehyde;5-(morpholin-4-yl)thiophene-2-carbaldehyde;MFCD02710611;2-Thiophenecarboxaldehyde,5-(4-morpholinyl)-;Oprea1_021727;SCHEMBL1432800;DTXSID10368108;BBL010061;STK500371;5-morpholinothiophene-2-carboxaldehyde;AKOS000115345;SB66972;A5028;BB 0218939;FT-0679279;5-(Morpholin-4-yl)thiophene-2-carboxaldehyde;EN300-01138;2-Thiophenecarboxaldehyde, 5-(4-morpholinyl)-;12Y-0703;J-517847;5-morpholin-4-ylthiophene-2-carbaldehyde, AldrichCPR;Z56797099;F1935-0006

Chemical Property of 5-Morpholino-2-thiophenecarbaldehyde

Chemical Property:

• Vapor Pressure: 4.86E-06mmHg at 25°C
• Melting Point: 126 °C
• Refractive Index: 1.607
• Boiling Point: 382 °C at 760 mmHg
• PKA: 1.49±0.20(Predicted)
• Flash Point: 184.8 °C
• PSA: 57.78000
• Density: 1.281 g/cm³
• LogP: 1.46220
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 197.05104977
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

98%min ^*data from raw suppliers

5-Morpholino-2-thiophenecarbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC=C(S2)C=O

Technology Process of 5-Morpholino-2-thiophenecarbaldehyde

There total 4 articles about 5-Morpholino-2-thiophenecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + 5-bromo-2-thiophencarboxaldehyde (4701-17-1) → 5-(4-morpholinyl)thiophene-2-carboxaldehyde (24372-49-4)

Guidance literature:

In water; for 12h; Heating;

DOI:10.1055/s-1998-1657

Reference yield: 45.0%

→ 5-(4-morpholinyl)thiophene-2-carboxaldehyde (24372-49-4)

Guidance literature:

Reference yield:

5-bromo-2-(bismorpholino)methyl thiophene → 5-(4-morpholinyl)thiophene-2-carboxaldehyde (24372-49-4)

Guidance literature:

In water; for 0.0833333h; Heating;

DOI:10.1016/S0040-4020(99)00318-X

upstream raw materials:

morpholine

5-bromo-2-thiophencarboxaldehyde

Downstream raw materials:

5-(4-morpholinyl)thiophene-2-carboxylic acid

Refernces

• 1、 Medimagh, Raouf,Marque, Sylvain,Prim, Damien,Chatti, Saber. "A facile preparation of trisubstituted amino-furan and -thiophene derivatives". scheme or table. p. 6055 - 6065. Retrieved 2011/10/08.
• 2、 Prim, Damien,Kirsch, Gilbert. "Convenient amination of weakly activated thiophenes, furans and selenophenes in aqueous media". . p. 6511 - 6526. Retrieved 2007/10/03.