4-(Hydroxymethyl)pyrrolidin-2-one

Base Information

Chemical Name:4-(Hydroxymethyl)pyrrolidin-2-one
CAS No.:64320-89-4
Molecular Formula:C5H9NO2
Molecular Weight:115.132
Hs Code.:2933790090
European Community (EC) Number:676-316-3
DSSTox Substance ID:DTXSID20570538
Mol file:64320-89-4.mol

Synonyms:4-(hydroxymethyl)pyrrolidin-2-one;64320-89-4;4-(Hydroxymethyl)-2-pyrrolidinone;4-Hydroxymethyl-2-pyrrolidinone;MFCD11845728;2-PYRROLIDINONE, 4-(HYDROXYMETHYL)-;MFCD19227460;4-Hydroxymethylpyrrolidin-2-one;SCHEMBL524142;4-hydroxymethyl pyrrolidin-2-one;4-Hydroxymethyl-pyrrolidin-2-one;DTXSID20570538;KTOFYLXSANIPND-UHFFFAOYSA-N;AKOS005172380;AS-5548;PB26709;PB48213;NCGC00339755-01;AC-25592;SY008749;SY343840;A8821;CS-0046664;4-(Hydroxymethyl)-2-pyrrolidinone, AldrichCPR;EN300-122320;P11209;AB01332251-02;F2147-0766;Z1201625841

Suppliers and Price of 4-(Hydroxymethyl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(Hydroxymethyl)-2-pyrrolidinone
500mg
$ 185.00

Synthonix
4-Hydroxymethyl-2-pyrrolidinone 95+%
1g
$ 120.00

SynQuest Laboratories
4-(Hydroxymethyl)pyrrolidin-2-one
5 g
$ 524.00

SynQuest Laboratories
4-(Hydroxymethyl)pyrrolidin-2-one
1 g
$ 152.00

Oakwood
4-Hydroxymethyl-2-pyrrolidinone tech
250mg
$ 75.00

Matrix Scientific
4-(Hydroxymethyl)pyrrolidin-2-one
1g
$ 130.00

Matrix Scientific
4-(Hydroxymethyl)pyrrolidin-2-one
500mg
$ 85.00

Crysdot
4-(Hydroxymethyl)pyrrolidin-2-one 95+%
5g
$ 333.00

Chemenu
4-(Hydroxymethyl)pyrrolidin-2-one 95%
5g
$ 311.00

Atlantic Research Chemicals
4-(Hydroxymethyl)pyrrolidin-2-one 95%
250mgs:
$ 49.48

Total 26 raw suppliers

Chemical Property of 4-(Hydroxymethyl)pyrrolidin-2-one

Chemical Property:

Boiling Point:345.953 °C at 760 mmHg
PKA:14.56±0.10(Predicted)
Flash Point:163.027 °C
PSA：49.33000
Density:1.153 g/cm³
LogP:-0.55640
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:115.063328530
Heavy Atom Count:8
Complexity:103

Purity/Quality:

99%, ^*data from raw suppliers

4-(Hydroxymethyl)-2-pyrrolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,N
Hazard Codes:Xi,N
Statements: 36-51/53
Safety Statements: 26-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CNC1=O)CO
Uses 4-(hydroxymethyl)pyrrolidin-2-one is an intermediate in the preparation of aminopiperidines and related compounds as MCH receptor modulators useful in the treatment of metabolic, feeding and sexual disorders in humans.

Technology Process of 4-(Hydroxymethyl)pyrrolidin-2-one

There total 5 articles about 4-(Hydroxymethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 35309-35-4,428518-31-4
5-oxopyrrolidine-3-carboxylic acid methyl ester

: 64320-89-4
4-(hydroxymethyl)-2-pyrrolidinone

Guidance literature:: With sodium tetrahydroborate; In isopropyl alcohol; at 0 - 20 ℃;

Reference yield: 59.0%

: 183062-94-4
1-Benzhydryl-4-hydroxymethyl-pyrrolidin-2-one

: 64320-89-4
4-(hydroxymethyl)-2-pyrrolidinone

Guidance literature:: With hydrogen; palladium hydroxide - carbon; In methanol; for 18h; under 2585.7 Torr;

Reference yield:

: 183062-93-3
1-Benzhydryl-4-hydroxymethyl-2-oxo-pyrrolidine-3-carboxylic acid

: 64320-89-4
4-(hydroxymethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 2 h / 130 °C / 2 Torr

2: 59 percent / H₂ / 20percent Pd(OH)2 on C / methanol / 18 h / 2585.7 Torr

With hydrogen; palladium hydroxide - carbon; In methanol;