nor-Mephedrone (hydrochloride)

Base Information

• Chemical Name: nor-Mephedrone (hydrochloride)
• CAS No.: 6941-17-9
• Molecular Formula: C10H13NO
• Molecular Weight: 199.68
• Mol file: 6941-17-9.mol

Synonyms:2-amino-1-p-tolylethanone;2-amino-1-p-tolyl-propan-1-one,hydrochloride;2-Amino-4 inverted exclamation mark-tolylacetophenone;4-Aminoacetyl-toluol;2-amino-4'-methylpropiophenone hydrochloride;2-Amino-4'-methylacetophenone;p-Tolacylamin;2-Amino-1-P-Tolyl-Ethanone Hydrochloride;2-Amino-1-p-tolyl-propan-1-on,Hydrochlorid;2-Amino-1-p-tolyl-aethanon;

Chemical Property of nor-Mephedrone (hydrochloride)

Chemical Property:

• Vapor Pressure: 0.00382mmHg at 25°C
• Melting Point: >168°C (dec.)
• Boiling Point: 280.3°Cat760mmHg
• Flash Point: 123.3°C
• PSA: 43.09000
• Density: 1.034g/cm³
• LogP: 3.02720
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

2-Amino-1-(4-methylphenyl)-1-propanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-1-(4-methylphenyl)-1-propanone, also known as Nor-mephedrone is a synthetic cathinone.

Technology Process of nor-Mephedrone (hydrochloride)

There total 6 articles about nor-Mephedrone (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C20H29NO5 → (rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride (6941-17-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 16h;

DOI:10.1111/bph.13547

Reference yield: 55.0%

(RS)-2-trifluoroacetamido-1-(4-methylphenyl)-1-propanone (742095-35-8) → (rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride (6941-17-9)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol;

DOI:10.1016/j.bmc.2004.05.033

Reference yield:

α-chloro-4-methyl propiophenone (69673-92-3) → (rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride (6941-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 24 h / 20 °C

2: hydrogenchloride / diethyl ether / 16 h / 20 °C

With hydrogenchloride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1111/bph.13547

upstream raw materials:

(RS)-2-trifluoroacetamido-1-(4-methylphenyl)-1-propanone

α-chloro-4-methyl propiophenone

4'-methylpropiophenone

2-bromo-4'-methylpropiophenone

Downstream raw materials:

2-amino-1-(4-methylphenyl)-1-propanol

Refernces

• 1、 Watanabe, Kazutoshi,Morinaka, Yasuhiro,Hayashi, Yoshio,Shinoda, Masaki,Nishi, Hiroyoshi,Fukushima, Nobuko,Watanabe, Toshiaki,Ishibashi, Akira,Yuki, Satoshi,Tanaka, Masahiko. "5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity". . p. 1478 - 1483. Retrieved 2008/09/18.