6-Aminofluorescein

Base Information

• Chemical Name: 6-Aminofluorescein
• CAS No.: 51649-83-3
• Molecular Formula: C20H13NO5
• Molecular Weight: 347.327
• Hs Code.: 29329990
• European Community (EC) Number: 257-334-7
• DSSTox Substance ID: DTXSID40199588
• Nikkaji Number: J207.903H
• Wikidata: Q72437037
• Mol file: 51649-83-3.mol

Synonyms:FCA II;fluoresceinamine isomer II

Chemical Property of 6-Aminofluorescein

Chemical Property:

• Appearance/Colour: yellow solid
• Vapor Pressure: 1.24E-20mmHg at 25°C
• Melting Point: 285 °C (dec.)(lit.)
• Refractive Index: 1.819
• Boiling Point: 706.65 °C at 760 mmHg
• PKA: 9.34±0.20(Predicted)
• Flash Point: 381.169 °C
• PSA: 102.01000
• Density: 1.65 g/cm³
• LogP: 3.82920
• Storage Temp.: 2-8°C
• Solubility.: methanol: soluble1mg/mL, clear, yellow to very dark yellow-orang
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 347.07937252
• Heavy Atom Count: 26
• Complexity: 557

Purity/Quality:

≥99.0% ^*data from raw suppliers

Fluoresceinamine, Isomer 2, ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1N)C3(C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O)OC2=O
• Uses: Glycosaminoglycuronans react with 6-aminofluorescein to yield fluorescent derivatives.

Technology Process of 6-Aminofluorescein

There total 6 articles about 6-Aminofluorescein which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6'-amino-3,6-dihydroxyspiro-3'-one (51649-83-3)

Guidance literature:

With ethanol; nickel; Hydrogenation;

DOI:10.1084/jem.91.1.1

Reference yield:

recorcinol (108-46-3) → 6'-amino-3,6-dihydroxyspiro-3'-one (51649-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 200 °C

2: sodium sulfide nonahydrate; sodium hydrogensulfide / water / 24 h / Reflux

With sodium hydrogensulfide; sodium sulfide nonahydrate; In water;

DOI:10.1021/ml300191g

Reference yield:

4'-nitrofluorescein (27402-68-2) → 6'-amino-3,6-dihydroxyspiro-3'-one (51649-83-3)

Guidance literature:

With sodium hydrogensulfide; sodium sulfide nonahydrate; In water; for 24h; Reflux;

DOI:10.1021/ml300191g

upstream raw materials:

4-amino-N-methylphthalimide

recorcinol

4'-nitrofluorescein

4-nitrophthalic acid

Downstream raw materials:

4-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid ethyl ester

C₄₂H₃₄N₂O₉S

fluorescein-5-isothiocyanate

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