Ftaxilide

Base Information

• Chemical Name: Ftaxilide
• CAS No.: 19368-18-4
• Molecular Formula: C16H15 N O3
• Molecular Weight: 269.3
• European Community (EC) Number: 666-316-1
• NSC Number: 758893,16112
• UNII: 7Z71845H3F
• DSSTox Substance ID: DTXSID5046300
• Nikkaji Number: J60.504B
• Wikidata: Q27269063
• NCI Thesaurus Code: C65773
• ChEMBL ID: CHEMBL1308252
• Mol file: 19368-18-4.mol

Synonyms:Ftaxilide;19368-18-4;Histanorm;2',6'-Dimethylphthalanilic acid;2-[(2,6-dimethylphenyl)carbamoyl]benzoic acid;Ftaxilidum;Ftaxilida;Ftaxilide [INN:DCF];Ftaxilidum [INN-Latin];Ftaxilida [INN-Spanish];Phthalic 2,6-dimethylanilide;2-(2,6-Dimethylphenylcarbamoyl)benzoic acid;MP 12;NSC 16112;NSC-16112;Phthalanilic acid, 2',6'-dimethyl-;BRN 2659992;DTXSID5046300;UNII-7Z71845H3F;MP-12-P;2-(((2,6-Dimethylphenyl)amino)carbonyl)benzoic acid;7Z71845H3F;Benzoic acid, 2-(((2,6-dimethylphenyl)amino)carbonyl)-;NCGC00160683-01;4-12-00-02527 (Beilstein Handbook Reference);DTXCID3026300;CAS-19368-18-4;2-((2,6-Dimethylphenyl)carbamoyl)benzoic acid;SR-01000253137;2-{[(2,6-dimethylphenyl)amino]carbonyl}benzoic acid;Ftaxilid;Ftaxilide [DCF:INN];FTAXILIDE [INN];D09WFL;Oprea1_160752;MLS000876772;TSI-GSD-223;SCHEMBL1170617;Phthalanilic acid,6'-dimethyl-;CHEMBL1308252;HMS2981J15;HMS3264M09;MP-12;Pharmakon1600-01504523;HY-B1040;NSC16112;Tox21_111986;MFCD00029943;NSC758893;s6464;STK267964;ZH548-M12;Rift Valley fever vaccine, USAMRIID;AKOS001678089;Tox21_111986_1;CCG-213931;CS-4559;N-(2,6-XYLYL)PHTHALAMIC ACID;NSC-758893;NCGC00160683-03;AS-76726;SMR000673583;SBI-0207060.P001;LS-109102;2-[(2,6-dimethylanilino)carbonyl]benzoic acid;C73685;AB00865150_06;AK-918/41204433;2-(2,6-Dimethylphenylcarbamoyl)benzoic acid, 97%;SR-01000253137-1;SR-01000253137-3;BRD-K05724540-001-04-4;Q27269063

Chemical Property of Ftaxilide

Chemical Property:

• Vapor Pressure: 2.68E-06mmHg at 25°C
• Melting Point: 188-189 °C(Solv: ethanol (64-17-5))
• Boiling Point: 375.3°Cat760mmHg
• PKA: 3.45±0.36(Predicted)
• Flash Point: 180.8°C
• PSA: 66.40000
• Density: 1.262g/cm³
• LogP: 3.32690
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Soluble in (10 mM DMSO).
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 269.10519334
• Heavy Atom Count: 20
• Complexity: 359

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2,6-XYLYL)PHTHALAMIC ACID Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2=CC=CC=C2C(=O)O
• Uses: It is used as a novel antituberculosis agent.

Technology Process of Ftaxilide

There total 2 articles about Ftaxilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) + 2,6-dimethylaniline (87-62-7) → N-(2,6-dimethyl-phenyl)-phthalamic acid (19368-18-4)

Guidance literature:

With acetic acid;

DOI:10.1021/ja01592a026

Reference yield:

→ N-(2,6-dimethyl-phenyl)-phthalamic acid (19368-18-4)

Guidance literature:

Phthalsaeureanhydrid, 2,6-Dimethyl-anilin, Bzl., Δ;

Reference yield:

N-(2,6-dimethyl-phenyl)-phthalamic acid (19368-18-4) → 2-hydroxymethyl-benzoic acid-(2,6-dimethyl-anilide) (134750-55-3)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01592a026

upstream raw materials:

phthalic anhydride

2,6-dimethylaniline

Downstream raw materials:

2-hydroxymethyl-benzoic acid-(2,6-dimethyl-anilide)

2-(2,6-dimethyl-anilinomethyl)-benzyl alcohol

2-(phenylcarbamoyloxy-methyl)-benzoic acid-(2,6-dimethyl-anilide)