N-(6-formyl-4-oxo-1H-pteridin-2-yl)acetamide

Base Information

• Chemical Name: N-(6-formyl-4-oxo-1H-pteridin-2-yl)acetamide
• CAS No.: 29769-49-1
• Molecular Formula: C9H7 N5 O3
• Molecular Weight: 233.186
• Mol file: 29769-49-1.mol

Synonyms:6-Pteridinecarboxaldehyde,2-acetamido-4-hydroxy- (6CI,7CI); Acetamide, N-(6-formyl-1,4-dihydro-4-oxo-2-pteridinyl)-(9CI); 2-Acetamido-6-formylpteridin-4(3H)-one; NSC 129965

Chemical Property of N-(6-formyl-4-oxo-1H-pteridin-2-yl)acetamide

Chemical Property:

• Melting Point: >215°C (dec.)
• Boiling Point: °Cat760mmHg
• PKA: 7.45±0.20(Predicted)
• Flash Point: °C
• PSA: 117.70000
• Density: 1.72g/cm³
• LogP: -0.44300
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Acetamido-6-formylpteridin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: pteridine derivative

Technology Process of N-(6-formyl-4-oxo-1H-pteridin-2-yl)acetamide

There total 13 articles about N-(6-formyl-4-oxo-1H-pteridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

acetic anhydride (108-24-7) + 6-pterinaldehyde (712-30-1) → N(2')-acetyl-6-formylpterin (29769-49-1)

Guidance literature:

at 130 ℃; for 4h;

DOI:10.1002/jlcr.2580361010

Reference yield: 69.0%

6-formylpterin (712-30-1) + acetic anhydride (108-24-7) → 2-acetylamino-4-hydroxy-6-formylpteridine (29769-49-1)

Guidance literature:

at 100 ℃; for 10h;

DOI:10.1021/jf025571k

Reference yield: 67.0%

2-acetylamino-4-hydroxy-6-formylpteridine dimethyl acetal → 2-acetylamino-4-hydroxy-6-formylpteridine (29769-49-1)

Guidance literature:

With formic acid; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2016.07.006

upstream raw materials:

N-(6-diethoxymethyl-4-oxo-3,4-dihydro-pteridin-2-yl)-acetamide

N-(6-methyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide

N^2'-acetyl-6-diacetoxymethylpterin

6-formylpterin

Downstream raw materials:

N⁽²⁾-acetylfolic acid

N-{4-[(2-acetylamino-4-oxo-3,4-dihydro-pteridin-6-ylmethylen)-amino]-benzoyl}-L-glutamic acid

N-{2-[(2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-amino]-thiazole-5-carbonyl}-glutamic acid

N-(N²-acetyl-10-formyl-pteroyl)-L-glutamic acid