(2-Fluorophenyl)(1-methyl-4-piperidinyl)-methanone Hydrochloride

Base Information

• Chemical Name: (2-Fluorophenyl)(1-methyl-4-piperidinyl)-methanone Hydrochloride
• CAS No.: 64671-30-3
• Molecular Formula: C13H16FNO.ClH
• Molecular Weight: 257.73200
• DSSTox Substance ID: DTXSID10525113
• Mol file: 64671-30-3.mol

Synonyms:64671-30-3;(2-Fluorophenyl)(1-methyl-4-piperidinyl)-methanone Hydrochloride;(2-fluorophenyl)-(1-methylpiperidin-4-yl)methanone;hydrochloride;(2-Fluorophenyl)(1-methylpiperidin-4-yl)methanone hydrochloride;NWVKAOJRWMSFMU-UHFFFAOYSA-N;starbld0024939;SCHEMBL10395819;DTXSID10525113;AKOS030255309;4-(2-Fluorobenzoyl)-1-methylpiperidine hydrochloride;(2-Fluorophenyl)(1-methylpiperidin-4-yl)methanone--hydrogen chloride (1/1);(6R,7R)-7-Amino-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Diphenylmethyl Ester Hydrochloride

Chemical Property of (2-Fluorophenyl)(1-methyl-4-piperidinyl)-methanone Hydrochloride

Chemical Property:

• PSA: 20.31000
• LogP: 3.09010
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 257.0982700
• Heavy Atom Count: 17
• Complexity: 248

Purity/Quality:

97% ^*data from raw suppliers

(2-Fluorophenyl)(1-methyl-4-piperidinyl)-methanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC(CC1)C(=O)C2=CC=CC=C2F.Cl
• Uses: (2-Fluorophenyl)(1-methyl-4-piperidinyl)-methanone Hydrochloride (cas# 64671-30-3) is a compound useful in organic synthesis.

Technology Process of (2-Fluorophenyl)(1-methyl-4-piperidinyl)-methanone Hydrochloride

There total 2 articles about (2-Fluorophenyl)(1-methyl-4-piperidinyl)-methanone Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-1-methylpiperidine (5570-77-4) + ethereal hydrogen chloride + 2-fluorobenzonitrile (394-47-8) → 4-(2-fluorobenzoyl)-1-methylpiperidine hydrochloride (64671-30-3)

Guidance literature:

With ammonium chloride; magnesium; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield:

4-chloro-1-methylpiperidine (5570-77-4) + 2-fluorobenzonitrile (394-47-8) → 4-(2-fluorobenzoyl)-1-methylpiperidine hydrochloride (64671-30-3)

Guidance literature:

With ethereal hydrochloric acid; ammonium chloride; magnesium; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield:

4-(2-fluorobenzoyl)-1-methyl piperidine (84163-45-1) + 2-methoxyphenylhydrazine hydrochloride (6971-45-5,57396-67-5) + 4-(2-fluorobenzoyl)-1-methylpiperidine hydrochloride (64671-30-3) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → 1-(2-methoxyphenyl)-3-(1-methyl-4-piperidinyl)-1H-indazole fumarate

Guidance literature:

With NaH; sodium acetate; In N,N-dimethyl-formamide; butan-1-ol;

upstream raw materials:

4-chloro-1-methylpiperidine

2-fluorobenzonitrile

Refernces

• 1、 -. "3-(4-Piperidinyl)-1,2-benzisothiazoles". . . Retrieved 2008/06/13.