Benzenesulfonic acid, 4-methyl-, (2,2-dimethylcyclohexylidene)hydrazide, (E)-

Base Information

Chemical Name:Benzenesulfonic acid, 4-methyl-, (2,2-dimethylcyclohexylidene)hydrazide, (E)-
CAS No.:64692-82-6
Molecular Formula:C₁₅H₂₂N₂O₂S
Molecular Weight:294.418
Hs Code.:

Synonyms:

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Chemical Property of Benzenesulfonic acid, 4-methyl-, (2,2-dimethylcyclohexylidene)hydrazide, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of Benzenesulfonic acid, 4-methyl-, (2,2-dimethylcyclohexylidene)hydrazide, (E)-

There total 1 articles about Benzenesulfonic acid, 4-methyl-, (2,2-dimethylcyclohexylidene)hydrazide, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1193-47-1
2,2-dimethyl-cyclohexanone

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 64692-82-6
2,2-dimethylcyclohexanone (p-tolylsulfonyl)hydrazone

Guidance literature:: With hydrogenchloride; for 0.0166667h; Heating;
DOI:10.1021/jo00252a037

Reference yield:

: 64692-82-6
2,2-dimethylcyclohexanone (p-tolylsulfonyl)hydrazone

: 54445-54-4
(+/-)-methyl 2-methylene-1-cyclohexaneacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) TMEDA, n-BuLi / 1.) hexanes, a.) -78 deg C, 60 min b.) RT, 1.5h; 2.) RT 3h.

2: diisobutylammonium hydride / CH₂Cl₂; hexane / 3 h / -78 °C

3: 75 percent / triethylamine, DMAP / CH₂Cl₂ / 0.5 h / 0 °C

4: 1.) LDA / 1.) hexane, THF, -78 deg C, 10 min, 2.) reflux, 2h

5: 1.) LDA / 1.) hexane, THF, -78 deg C, 10 min, 2.) reflux, 2h

6: 5percent aq. NaOH

7: diethyl ether / 0.5 h / 0 °C

With dmap; sodium hydroxide; n-butyllithium; Diisobutylammonium hydride; N,N,N,N,-tetramethylethylenediamine; triethylamine; lithium diisopropyl amide; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo00252a037

Reference yield:

: 64692-82-6
2,2-dimethylcyclohexanone (p-tolylsulfonyl)hydrazone

: 115463-60-0,115510-93-5,115510-94-6,115510-95-7
methyl (1R*,αS*,1'S*)-(+/-)-3,3-dimethyl-α-(1'-hydroxyethyl)-2-methylene-1-cyclohexane-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) TMEDA, n-BuLi / 1.) hexanes, a.) -78 deg C, 60 min b.) RT, 1.5h; 2.) RT 3h.

2: diisobutylammonium hydride / CH₂Cl₂; hexane / 3 h / -78 °C

3: 75 percent / triethylamine, DMAP / CH₂Cl₂ / 0.5 h / 0 °C

4: 1.) LiHMDS / 1.) THF, -78 deg C, 15 min; 2.) 10 min

5: 57 percent / lithuim diisopropylamide / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) RT, 6 h, 3.) 50 deg C, 12 h.

6: diethyl ether / 0.5 h / 0 °C

With dmap; n-butyllithium; Diisobutylammonium hydride; N,N,N,N,-tetramethylethylenediamine; triethylamine; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo00252a037