Glycine, N-(N-L-phenylalanyl-L-phenylalanyl)-, phenylmethyl ester, monohydrochloride

Base Information

• Chemical Name: Glycine, N-(N-L-phenylalanyl-L-phenylalanyl)-, phenylmethyl ester, monohydrochloride
• CAS No.: 64698-98-2
• Molecular Formula: C27H29N3O4.ClH
• Molecular Weight: 496.006
• Mol file: 64698-98-2.mol

Synonyms:

Chemical Property of Glycine, N-(N-L-phenylalanyl-L-phenylalanyl)-, phenylmethyl ester, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Glycine, N-(N-L-phenylalanyl-L-phenylalanyl)-, phenylmethyl ester, monohydrochloride

There total 1 articles about Glycine, N-(N-L-phenylalanyl-L-phenylalanyl)-, phenylmethyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Phe-Phe-Gly-OBzl (64698-97-1) → Phe-Phe-Gly-OBzl*HCl (64698-98-2)

Guidance literature:

With hydrogenchloride; In acetic acid; for 1h; Ambient temperature;

DOI:10.1021/jm00157a028

Reference yield:

Phe-Phe-Gly-OBzl*HCl (64698-98-2) → Boc-Thr(OCH3)-Phe-Phe-Gly-OH (102979-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBt), N,N- dicyclohexylcarbodiimide (DCC) / dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, 24 h

2: 92 percent / H₂ / 10percent Pd/C / dimethylformamide; H₂O

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm00157a028

Reference yield:

Phe-Phe-Gly-OBzl*HCl (64698-98-2) → Boc-Val-Phe-Phe-Gly-Leu-Met-NH2 (102979-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBt), N,N- dicyclohexylcarbodiimide (DCC) / dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, 24 h

2: 90 percent / H₂ / 10percent Pd/C / dimethylformamide; H₂O

3: N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBt), N,N- dicyclohexylcarbodiimide (DCC) / dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, 24 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm00157a028

upstream raw materials:

Boc-Phe-Phe-Gly-OBzl

Downstream raw materials:

Boc-Thr(OCH₃)-Phe-Phe-Gly-OBzl

Boc-Orn(Boc)-Phe-Phe-Gly-OH

Boc-Val-Phe-Phe-Gly-OH

Boc-Thr-Phe-Phe-Gly-OH