4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide

Base Information

Chemical Name:4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide
CAS No.:64724-85-2
Molecular Formula:C₁₀H₇N₃O₄S
Molecular Weight:265.249
Hs Code.:
DSSTox Substance ID:DTXSID901267909
ChEMBL ID:CHEMBL1801513

Synonyms:CHEMBL1801513;SCHEMBL12974167;DTXSID901267909;4-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide;4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide;64724-85-2

Suppliers and Price of 4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:265.01572689
Heavy Atom Count:18
Complexity:328

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-])O

Technology Process of 4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide

There total 3 articles about 4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-96-7
4-hydroxy-benzoic acid

: 64724-85-2
4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water / 0 - 20 °C

2: thionyl chloride; pyridine / dichloromethane / Reflux

3: triethylamine / tetrahydrofuran / -15 °C / Reflux

4: hydrogenchloride; sulfuric acid; water / 50 °C

With pyridine; hydrogenchloride; thionyl chloride; sulfuric acid; water; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/acsmedchemlett.0c00544

Reference yield:

: 2345-34-8
4-acetyloxy-benzoic acid

: 64724-85-2
4-hydroxy-N-(5-nitrothiazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; pyridine / dichloromethane / Reflux

2: triethylamine / tetrahydrofuran / -15 °C / Reflux

3: hydrogenchloride; sulfuric acid; water / 50 °C

With pyridine; hydrogenchloride; thionyl chloride; sulfuric acid; water; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acsmedchemlett.0c00544