5-Isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil

Base Information

Chemical Name:5-Isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil
CAS No.:137897-89-3
Molecular Formula:C18H24 N2 O3 S2
Molecular Weight:380.532
Hs Code.:
DSSTox Substance ID:DTXSID10160381
Nikkaji Number:J457.574A
ChEMBL ID:CHEMBL274265
Mol file:137897-89-3.mol

Synonyms:5-isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil;I-HEPU-SdM

Suppliers and Price of 5-Isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-Isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：124.90000
Density:1.29g/cm³
LogP:4.17600
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:380.12283498
Heavy Atom Count:25
Complexity:526

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC(=C1)SC2=C(C(=O)NC(=S)N2COCCO)C(C)C)C

Technology Process of 5-Isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil

There total 4 articles about 5-Isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(3,5-dimethyl-phenylsulfanyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

: 137897-89-3
6-<(3,5-dimethylphenyl)thio>-5-isopropyl-1-<(2-hydroxyethoxy)methyl>-2-thiouracil

Guidance literature:: With hydrogenchloride; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jm00080a020

Reference yield:

: 65151-60-2
3,5,3',5'-tetramethyldiphenyldissulfide

: 137897-89-3
6-<(3,5-dimethylphenyl)thio>-5-isopropyl-1-<(2-hydroxyethoxy)methyl>-2-thiouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: HCl (conc.) / 2 h / Ambient temperature

With hydrogenchloride; lithium diisopropyl amide;
DOI:10.1021/jm00080a020

Reference yield:

: 137897-85-9
1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-5-isopropyl-2-thiouracil

: 137897-89-3
6-<(3,5-dimethylphenyl)thio>-5-isopropyl-1-<(2-hydroxyethoxy)methyl>-2-thiouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: HCl (conc.) / 2 h / Ambient temperature

With hydrogenchloride; lithium diisopropyl amide;
DOI:10.1021/jm00080a020