3-BROMO-4-HYDROXYQUINOLINE

Base Information

• Chemical Name: 3-BROMO-4-HYDROXYQUINOLINE
• CAS No.: 64965-47-5
• Molecular Formula: C9H6BrNO
• Molecular Weight: 224.057
• Hs Code.: 2933499090
• Mol file: 64965-47-5.mol

Synonyms:

Chemical Property of 3-BROMO-4-HYDROXYQUINOLINE

Chemical Property:

• Vapor Pressure: 0.00205mmHg at 25°C
• Melting Point: 282 °C
• Boiling Point: 307.4±22.0 °C(Predicted)
• PKA: 1.67±0.50(Predicted)
• Density: 1.705±0.06 g/cm3(Predicted)

Purity/Quality:

99.3% ^*data from raw suppliers

3-Bromoquinolin-4-ol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-4-HYDROXYQUINOLINE

There total 6 articles about 3-BROMO-4-HYDROXYQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

quinolin-4-ol (611-36-9) → 3-bromo-4-hydroxyquinoline (64965-47-5)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1039/d1cc04335h

Reference yield:

3-bromo-4-hydroxy-quinoline-2-carboxylic acid (861357-59-7) → 3-bromo-4-hydroxyquinoline (64965-47-5)

Guidance literature:

at 290 ℃;

Reference yield:

3-bromo-4-hydroxy-quinoline-2-carboxylic acid methyl ester (495409-73-9) → 3-bromo-4-hydroxyquinoline (64965-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NaOH

2: diphenyl ether; biphenyl / 180 °C

With sodium hydroxide; diphenylether; biphenyl;

DOI:10.1021/ja01216a044

upstream raw materials:

quinolin-4-ol

3-bromo-4-hydroxy-quinoline-2-carboxylic acid

3-bromo-4-hydroxy-quinoline-2-carboxylic acid methyl ester

Downstream raw materials:

3-bromo-4-chloroquinoline

3,4-dibromoquinoline

3-bromo-4-methoxy-quinoline

4-(4-chlorophenyl)-3-(p-tosyl)quinoline hydrochloride

Refernces

• 1、 Piala, Alexander,Mayi, Diyar,Handy, Scott T.. "Studies of one-pot double couplings on dibromoquinolines". experimental part. p. 4147 - 4154. Retrieved 2011/07/08.