2-hydroxy-4-phenylbutyric acid

Base Information

• Chemical Name: 2-hydroxy-4-phenylbutyric acid
• CAS No.: 4263-93-8
• Molecular Formula: C10H12 O3
• Molecular Weight: 180.203
• Mol file: 4263-93-8.mol

Synonyms:Butyricacid, 2-hydroxy-4-phenyl- (6CI,7CI,8CI); (RS)-2-Hydroxy-4-phenylbutyric acid; (?à)-2-Hydroxy-4-phenylbutanoicacid; 2-Hydroxy-4-phenylbutanoic acid; 2-Hydroxy-4-phenylbutyric acid;4-Phenyl-2-hydroxybutanoic acid; NSC 55316; a-Hydroxy-g-phenylbutyric acid; g-Phenyl-a-hydroxybutyricacid

Chemical Property of 2-hydroxy-4-phenylbutyric acid

Chemical Property:

• Vapor Pressure: 1.03E-05mmHg at 25°C
• Melting Point: 105-106℃ (benzene )
• Boiling Point: 356.9°Cat760mmHg
• PKA: 3.79±0.10(Predicted)
• Flash Point: 183.9°C
• PSA: 57.53000
• Density: 1.219g/cm³
• LogP: 1.06470

Purity/Quality:

99% ^*data from raw suppliers

2-hydroxy-4-phenylbutanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxy-4-phenylbutyric acid

There total 43 articles about 2-hydroxy-4-phenylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

sodium salt of benzylidenepyruvic acid → 2-hydroxy-4-phenylbutanoic acid (4263-93-8,111611-91-7)

Guidance literature:

With hydrogen; nickel; In ethanol; at 20 ℃; for 9h;

Reference yield: 91.0%

phosphoric acid 1-cyano-3-phenylpropyl ester diethyl ester (855476-42-5,887628-50-4) → 2-hydroxy-4-phenylbutanoic acid (4263-93-8,111611-91-7)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1248/cpb.54.397

Reference yield: 90.0%

LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + benzyl alcohol (100-51-6,185532-71-2) → 2-hydroxy-4-phenylbutanoic acid (4263-93-8,111611-91-7)

Guidance literature:

LACTIC ACID; With potassium hydroxide; In water; toluene; Cooling with ice; Heating; Dean-Stark apparatus;

benzyl alcohol; With nickel(II) acetate tetrahydrate; at 155 - 165 ℃; for 3h;

DOI:10.1002/adsc.201100241

upstream raw materials:

(E)-2-oxo-4-phenyl-3-butenoic acid

2-oxo-4-phenylbutyric acid

phenyl-1,2-butanedione

benzylidene pyruvic acid

Downstream raw materials:

(RS)-2-hydroxy-4-phenylbutanoic acid methyl ester

3-Phenylpropionic acid

(R)-2-hydroxy4-phenylbutanoic acid

benzyl 2(R)-hydroxy-4-phenylbutyrate