Chemical Property of Secoxyloganin
Chemical Property:
- Vapor Pressure:1.29E-19mmHg at 25°C
- Boiling Point:649.5°Cat760mmHg
- PKA:4.40±0.10(Predicted)
- Flash Point:231.8°C
- PSA：172.21000
- Density:1.49g/cm3
- LogP:-1.89080
- Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
- XLogP3:-1.6
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:11
- Rotatable Bond Count:8
- Exact Mass:404.13186158
- Heavy Atom Count:28
- Complexity:618
- Purity/Quality:
-
99%, *data from raw suppliers
Secoxyloganin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC(=O)C1=COC(C(C1CC(=O)O)C=C)OC2C(C(C(C(O2)CO)O)O)O
- Isomeric SMILES:COC(=O)C1=CO[C@H]([C@@H]([C@@H]1CC(=O)O)C=C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
-
Description
Secoxyloganin is a secoiridoid glycoside that has been found in L. japonica and has diverse biological activities. It is active against E. coli and S. aureus in a disc assay when used at a concentration of 2 mg/disc. Secoxyloganin is cytotoxic to human dermal fibroblasts (IC50 = 78.1 μM). In vivo, secoxyloganin (10 mg/ml) prevents hen egg white lysozyme-induced decreases in tail vein blood flow, a marker of allergic inflammation, in hen egg white lysozyme-sensitized mice.
-
Uses
Secoxyloganin is a component of Poraqueiba sericea stems and may be used for its cytotoxic activity.
