Technology Process of (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R)-1-hydroxy-2-methyl-propyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecon
There total 2 articles about (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R)-1-hydroxy-2-methyl-propyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecon which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
In
dichloromethane;
for 42h;
Ambient temperature;
DOI:10.1021/jm00156a014
- Guidance literature:
-
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 3 h / -20 °C
2: 58 percent / (N,N-dimethylamino)pyridine, <(benzotriazol-1-yl)oxy>tris(dimethylamino)phosphonium hexafluorophosphate (BOP) / CH2Cl2 / 42 h / Ambient temperature
With
dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/jm00156a014