5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, diphenylmethyl ester, (6R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, diphenylmethyl ester, (6R)-
CAS No.:65058-69-7
Molecular Formula:C₂₄H₂₄N₆O₄S₂
Molecular Weight:524.624
Hs Code.:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
7-amino-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,
diphenylmethyl ester, (6R)-

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, diphenylmethyl ester, (6R)-

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Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, diphenylmethyl ester, (6R)-

There total 4 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, diphenylmethyl ester, (6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83934-79-6
(S)-7-[(Z)-2-Chloro-3-phenyl-prop-2-en-(E)-ylideneamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 56610-72-1,65058-69-7
diphenylmethyl 7β-amino-7α-methoxy-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>-3-cephem-4-carboxylate

Guidance literature:: With girard's reagent T; toluene-4-sulfonic acid; In methanol; ethyl acetate; at -40 ℃; for 1h;
DOI:10.1016/S0040-4039(00)87510-3

Reference yield:

: 53090-86-1
(R)-7-Amino-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 56610-72-1,65058-69-7
diphenylmethyl 7β-amino-7α-methoxy-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / CH₂Cl₂; ethyl acetate / azeotropic distillation

2: 87 percent / borax / acetonitrile / 2 h / 0 °C

3: p-TsOH, Girard T / ethyl acetate; methanol / 1 h / -40 °C

With borax; girard's reagent T; toluene-4-sulfonic acid; In methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(00)87510-3

Reference yield:

: 83934-73-0
(R)-3-(1-Methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-[2,2,3-trichloro-3-phenyl-prop-(E)-ylideneamino]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 56610-72-1,65058-69-7
diphenylmethyl 7β-amino-7α-methoxy-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / borax / acetonitrile / 2 h / 0 °C

2: p-TsOH, Girard T / ethyl acetate; methanol / 1 h / -40 °C

With borax; girard's reagent T; toluene-4-sulfonic acid; In methanol; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(00)87510-3